Nature Communications (Nov 2017)
Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma
- Raffaele Simeoli,
- Karli Montague,
- Hefin R. Jones,
- Laura Castaldi,
- David Chambers,
- Jayne H. Kelleher,
- Valentina Vacca,
- Thomas Pitcher,
- John Grist,
- Hadil Al-Ahdal,
- Liang-Fong Wong,
- Mauro Perretti,
- Johnathan Lai,
- Peter Mouritzen,
- Paul Heppenstall,
- Marzia Malcangio
Affiliations
- Raffaele Simeoli
- Wolfson Centre for Age Related Diseases, King’s College London
- Karli Montague
- Wolfson Centre for Age Related Diseases, King’s College London
- Hefin R. Jones
- The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London
- Laura Castaldi
- EMBL Monterotondo
- David Chambers
- Wolfson Centre for Age Related Diseases, King’s College London
- Jayne H. Kelleher
- Wolfson Centre for Age Related Diseases, King’s College London
- Valentina Vacca
- Wolfson Centre for Age Related Diseases, King’s College London
- Thomas Pitcher
- Wolfson Centre for Age Related Diseases, King’s College London
- John Grist
- Wolfson Centre for Age Related Diseases, King’s College London
- Hadil Al-Ahdal
- School of Clinical Sciences, Medical Science Building, University of Bristol
- Liang-Fong Wong
- School of Clinical Sciences, Medical Science Building, University of Bristol
- Mauro Perretti
- The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London
- Johnathan Lai
- Exiqon A/S
- Peter Mouritzen
- Exiqon A/S
- Paul Heppenstall
- EMBL Monterotondo
- Marzia Malcangio
- Wolfson Centre for Age Related Diseases, King’s College London
- DOI
- https://doi.org/10.1038/s41467-017-01841-5
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
Exosomes are known to contain microRNAs (miRs). Here the authors show that dorsal root ganglion neurons release exosomes containing miR-21-5p, which contributes to inflammatory cell recruitment following peripheral nerve injury.
