Research progress in pathogenesis of the pyoderma gangrenousum

Abstract

Pyoderma gangrenosum (PG) is a neutrophilic dermatosis with unknown origin. Genetic factors, neutrophil dysfunction, complement system dysregulation and aberrant cytokine secretion play important parts in its pathogenesis. This article will make a review of the pathogenesis of the pyoderma gangrenosum from the aspects mentioned above.

Keywords

• pyoderma gangrenosum
• pathogenesis
• neutrophilic dermatoses
• cytokine