Metabolomics Reveal Potential Natural Substrates of AcrB in Escherichia coli and Salmonella enterica Serovar Typhimurium
Xuan Wang-Kan,
Giovanny Rodríguez-Blanco,
Andrew D. Southam,
Catherine L. Winder,
Warwick B. Dunn,
Alasdair Ivens,
Laura J. V. Piddock
Affiliations
Xuan Wang-Kan
Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, United Kingdom
Giovanny Rodríguez-Blanco
School of Biosciences, The University of Birmingham, Birmingham, United Kingdom
Andrew D. Southam
School of Biosciences, The University of Birmingham, Birmingham, United Kingdom
Catherine L. Winder
School of Biosciences, The University of Birmingham, Birmingham, United Kingdom
Warwick B. Dunn
School of Biosciences, The University of Birmingham, Birmingham, United Kingdom
Alasdair Ivens
Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom
Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, United Kingdom
Multidrug-resistant Gram-negative bacteria pose a global threat to human health. The AcrB efflux pump confers inherent and evolved drug resistance to EnterobacteralesEscherichia coliSalmonella enterica
