Key Intermediates for Building the ω-Side Chain of Prostaglandins with a Constrained Pentalenofurane Scaffold Linked to C-15 Carbon Atom to Diminish the PG Inactivation

Abstract

The inactivation of prostaglandin (PG) and prostaglandin analogs (PGs) is realized with enzyme oxidation of the 15α-OH to the 15-keto group via the 15-PGDH pathway [...]

Keywords

• halogeno-pentalenofurane scaffold
• pentalenofurane esters
• penalenofurane-β-ketophosphonates
• 15-bulky prostaglandin substituents
• PGF1 analog
• X-ray analysis