Preventive Maintenance of Bacterial Complications at Newborns with the Respiratory Distress-Syndrome by Human Recombinant granulocyte Colony-Stimulating Factor

Abstract

Purpose: Definition of immunological criteria of purpose of rhGCSF became research aim newborns with respiratory distress syndrome, being on PPV. Materials and Methods: At 64 newborns determined at receipt: G-CSF, FRF, sFas, IL-6, IL-8, IL-4, IL-1, TNF (IFA), subpopulational structure of lymphocytes and level of lymphocytes in early and late apoptosis (flow cytometry with colouring annexin and propidium iodide; Beckman Coulter Epics, USA). Summary: Criteria for prescription of rhGCSF are decrease of plasma level of endogenous hr-GCSF low 1556 pg/ml and increase of lymphocytes, being in early and late apoptosis, above 9,5% and 0,56% (accordingly). Realization of randomized studies use rh-GCSF at newborns to development of neutropenic is necessary.

Keywords

• neutropenia
• sepsis
• newborn
• cytokin
• apoptosis