Unusual immunophenotypic variant of large B-cell lymphoma associated with HHV-8 and EBV in an HIV positive patient

Roberto Ruiz-Cordero, MD; Jenna Lewis, MD; Clifford Blieden, MD; German Campuzano-Zuluaga, MD; Jose Hernandez, MD; Izidore S. Lossos, MD; Francis Ikpatt, MD; Jennifer R. Chapman, MD; Francisco Vega, MD, PhD

doi:10.1016/j.ehpc.2015.02.002

Human Pathology: Case Reports (Jun 2015)

Unusual immunophenotypic variant of large B-cell lymphoma associated with HHV-8 and EBV in an HIV positive patient

Roberto Ruiz-Cordero, MD,
Jenna Lewis, MD,
Clifford Blieden, MD,
German Campuzano-Zuluaga, MD,
Jose Hernandez, MD,
Izidore S. Lossos, MD,
Francis Ikpatt, MD,
Jennifer R. Chapman, MD,
Francisco Vega, MD, PhD

Affiliations

Roberto Ruiz-Cordero, MD: Division of Hematopathology, Department of Pathology, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL 33136
Jenna Lewis, MD: Division of Hematopathology, Department of Pathology, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL 33136
Clifford Blieden, MD: Division of Hematopathology, Department of Pathology, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL 33136
German Campuzano-Zuluaga, MD: Division of Hematopathology, Department of Pathology, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL 33136
Jose Hernandez, MD: Department of Pathology at the Mercy Hospital, Miami, FL 33136
Izidore S. Lossos, MD: Division of Hematology-Oncology, Department of Medicine, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL 33136
Francis Ikpatt, MD: Division of Hematopathology, Department of Pathology, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL 33136
Jennifer R. Chapman, MD: Division of Hematopathology, Department of Pathology, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL 33136
Francisco Vega, MD, PhD: Division of Hematopathology, Department of Pathology, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL 33136

DOI: https://doi.org/10.1016/j.ehpc.2015.02.002
Journal volume & issue: Vol. 2, no. 2
pp. 49 – 54

Abstract

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Human herpesvirus type 8, also known as Kaposi's sarcoma-associated herpesvirus (HHV-8/KSHV) has been associated with several lymphoproliferative disorders including Kaposi's sarcoma, primary effusion lymphoma (PEL), cases of multicentric Castleman's disease (MCD) including plasmablastic lymphoma associated with MCD, and germinotropic lymphoproliferative disorder. These lymphoproliferative disorders, with the exception of the latter, usually arise in HIV-positive or profoundly immunosuppressed patients. Herein, we describe an unusual large B-cell lymphoma in a 43 year-old male infected with HIV who presented with multiple lymphadenopathies. The tumor cells were positive for EBV, HHV-8/KSHV, CD20 (small subset), PAX5, and IgM and negative for CD138, and IgG. This lymphoma is difficult to classify following the 2008 WHO criteria and expands the current spectrum of viral-associated lymphomas.

Published in Human Pathology: Case Reports

ISSN: 2214-3300 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Pathology
Website: http://www.journals.elsevier.com/human-pathology-case-reports/

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