The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers

Burak H. Alver; Kimberly H. Kim; Ping Lu; Xiaofeng Wang; Haley E. Manchester; Weishan Wang; Jeffrey R. Haswell; Peter J. Park; Charles W. M. Roberts

doi:10.1038/ncomms14648

Nature Communications (Mar 2017)

The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers

Burak H. Alver,
Kimberly H. Kim,
Ping Lu,
Xiaofeng Wang,
Haley E. Manchester,
Weishan Wang,
Jeffrey R. Haswell,
Peter J. Park,
Charles W. M. Roberts

Affiliations

Burak H. Alver: Department of Biomedical Informatics, Harvard Medical School
Kimberly H. Kim: Department of Pediatric Oncology, Dana-Farber Cancer Institute
Ping Lu: Department of Pediatric Oncology, Dana-Farber Cancer Institute
Xiaofeng Wang: Department of Pediatric Oncology, Dana-Farber Cancer Institute
Haley E. Manchester: Department of Pediatric Oncology, Dana-Farber Cancer Institute
Weishan Wang: Department of Pediatric Oncology, Dana-Farber Cancer Institute
Jeffrey R. Haswell: Department of Pediatric Oncology, Dana-Farber Cancer Institute
Peter J. Park: Department of Biomedical Informatics, Harvard Medical School
Charles W. M. Roberts: Department of Pediatric Oncology, Dana-Farber Cancer Institute

DOI: https://doi.org/10.1038/ncomms14648
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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SWI/SNF chromatin remodelling complex is a major regulator of chromatin structure and of transcription. Here, using mouse embryonic fibroblasts and human rhabdoid tumour cells, the authors provide evidence that SWI/SNF functions as a regulator of enhancers.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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