Synthetic biology-instructed transdermal microneedle patch for traceable photodynamic therapy

Gang He; Yashi Li; Muhammad Rizwan Younis; Lian-Hua Fu; Ting He; Shan Lei; Jing Lin; Peng Huang

doi:10.1038/s41467-022-33837-1

Nature Communications (Oct 2022)

Synthetic biology-instructed transdermal microneedle patch for traceable photodynamic therapy

Gang He,
Yashi Li,
Muhammad Rizwan Younis,
Lian-Hua Fu,
Ting He,
Shan Lei,
Jing Lin,
Peng Huang

Affiliations

Gang He: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center
Yashi Li: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center
Muhammad Rizwan Younis: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center
Lian-Hua Fu: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center
Ting He: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center
Shan Lei: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center
Jing Lin: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center
Peng Huang: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center

DOI: https://doi.org/10.1038/s41467-022-33837-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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An effective delivery system and imaging method for 5-Aminolevulinic acid (5-ALA)-based photodynamic therapy facilitated by the conversion of 5-ALA to protoporphyrin IX (PpIX) are lacking. Here, reversing the hypoxic tumour microenvironment can increase the in vivo biosynthesis of PpIX through the regulation of PpIX-related synthetases for traceable photodynamic therapy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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