Cell Genomics (Nov 2021)
International federation of genomic medicine databases using GA4GH standards
- Adrian Thorogood,
- Heidi L. Rehm,
- Peter Goodhand,
- Angela J.H. Page,
- Yann Joly,
- Michael Baudis,
- Jordi Rambla,
- Arcadi Navarro,
- Tommi H. Nyronen,
- Mikael Linden,
- Edward S. Dove,
- Marc Fiume,
- Michael Brudno,
- Melissa S. Cline,
- Ewan Birney
Affiliations
- Adrian Thorogood
- ELIXIR-Luxembourg and Biocore, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg; Centre of Genomics and Policy, Department of Human Genetics, McGill University, Montreal, QC, Canada; Corresponding author
- Heidi L. Rehm
- Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA
- Peter Goodhand
- Global Alliance for Genomics and Health, Toronto, ON, Canada; Ontario Institute for Cancer Research, Toronto, ON, Canada
- Angela J.H. Page
- Broad Institute of MIT and Harvard, Cambridge, MA, USA; Global Alliance for Genomics and Health, Toronto, ON, Canada
- Yann Joly
- Centre of Genomics and Policy, Department of Human Genetics, McGill University, Montreal, QC, Canada
- Michael Baudis
- University of Zurich and Swiss Institute of Bioinformatics, Zurich, Switzerland
- Jordi Rambla
- Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain
- Arcadi Navarro
- Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain; Institute of Evolutionary Biology (UPF-CSIC), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain
- Tommi H. Nyronen
- CSC - IT Center for Science, Life Science Center, Espoo, Finland; ELIXIR-Europe (Finland), Wellcome Genome Campus, Hinxton, Cambridgeshire, UK
- Mikael Linden
- CSC - IT Center for Science, Life Science Center, Espoo, Finland; ELIXIR-Europe (Finland), Wellcome Genome Campus, Hinxton, Cambridgeshire, UK
- Edward S. Dove
- School of Law, University of Edinburgh, Edinburgh, UK
- Marc Fiume
- DNAstack, Toronto, ON, Canada
- Michael Brudno
- Department of Computer Science, University of Toronto and University Health Network, Toronto, ON, Canada
- Melissa S. Cline
- UC Santa Cruz Genomics Institute, Mail Stop: Genomics, 1156 High Street, Santa Cruz, CA 95064, USA
- Ewan Birney
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridgeshire, UK
- Journal volume & issue
-
Vol. 1,
no. 2
p. 100032
Abstract
We promote a shared vision and guide for how and when to federate genomic and health-related data sharing, enabling connections and insights across independent, secure databases. The GA4GH encourages a federated approach wherein data providers have the mandate and resources to share, but where data cannot move for legal or technical reasons. We recommend a federated approach to connect national genomics initiatives into a global network and precision medicine resource.
