Expressions and clinical significance of PDCD4 and B7-H4 in optic gliomas in children

Abstract

AIM: To study the expressions and clinical significance of PDCD4 and B7-H4 in optic gliomas in children. METHODS: We used immunohistochemistry to evaluate the expressions of PDCD4 and B7-H4 in specimens from 52 optic gliomas in children cases, and analyzed the correlation of PDCD4 and B7-H4 expression with clinicopathological factors children optic gliomas. RESULTS: PDCD4 expression reduced in optic glioma tissue: PDCD4 expression rate in 52 cases of optic glioma tissues decreasing was correlated with tumor malignancy increase(PPPCONCLUSION: Expressions of PDCD4 and B7-H4 may be clinically relevant to tumor malignancy of optic gliomas in children and prevention of metastasis and prediction of prognosis.

Keywords

• children
• optic
• gliomas
• PDCD4
• B7-H4