THIRTY-YEAR CHANGES IN AVERAGE BLOOD LIPIDS LEVELS IN POPULATIONS OF THE RUSSIAN FEDERATION AND THE USA

Abstract

Aim. To conduct a comparative study of the changes in blood lipids profiles in populations of the Russian Federation (RF) and the United States of America (USA) in different age and gender groups over the period from 1975 to 2014.Material and methods. Using a secondary analysis of data obtained from the RF population studies carried out in 1975-1982, the multicenter epidemiological study of cardiovascular diseases in different regions of the RF (ESSE-RF), conducted in 2012-2014, as well as the NHANES series of crosssectional surveys in the civilian non-institutionalized population of the USA (NHANES II in 1976-1980 and Continuous NHANES in 2007-2012), we evaluated average lipids in blood tests in men and women of different age groups, with a total number of 48,974 observations.Results. At present, in the RF population, as compared to the USA one, most age groups demonstrate a higher concentration of total cholesterol, i.e. p<0.05 in all groups except for men aged 25-34 years (distinctions are absent) and women aged 25-34 (the concentrations are lower in Russia, p=0.05); a higher concentration of high-density lipoprotein cholesterol, i.e. p<0.005 in all men and p≤0.05 in women younger than 45 years, while in women aged 45-54 years the differences are non-significant; in 55-64-year-old women high-density lipoprotein cholesterol is higher in the USA; the concentration of triglycerides in Russia is lower in comparison with the USA in all age groups of men and women (p<0.01). Over the three decades, the total cholesterol concentration has declined in both countries; the patterns in theUnited States in comparison withRussia are characterized by an increase in the concentration of high-density lipoprotein cholesterol in all age groups and by the absence of a negative trend in triglyceride concentrations.Conclusion. Currently, inRussia, the total cholesterol and low-density lipoprotein cholesterol levels are worse, while triglycerides and partly high-density lipoprotein cholesterol concentrations are better than in theUSA. In general, the thirty-year trends for the aggregate of lipid metabolism parameters are better in theUSA population as compared toRussia.

Keywords

• dyslipidemia
• risk factors
• cardiovascular diseases
• nhanes ii
• continuous nhanes
• esse-rf study