Influence of Vitamin D on the Indexes of Type 2 Diabetes Mellitus Compensation

Abstract

Background. Diabetes mellitus (DM) results in violation of all types of metabolism (first of all carbohydrate one), lesion of vessels, nerves, different organs and tissues. However, the influence of DM on the trace elements level is not well studied yet. In spite of a good arsenal of medicaments, attaining DM compensation is succeeded less than in 30 % patients. For this reason the search of new ways to improve carbohydrate metabolism remains actual. Objective: to reveal the deficiency of 25-hydroxyvitamin D and its correlation with carbohydrate metabolism. Materials and methods. Thirty-five patients with type 2 DM were examined, aged 55–74 years old, duration of disease was 2–4 years. The control group included 35 practically healthy people of the same age and sex. Serum levels of 25-hydroxyvitamin D were tested using radioimmunoassay. Level of glycated hemoglobin was tested using liquid chromatography method. Results. In 37.1 % patients with type 2 DM deficit of vitamin D is educed. Thus in 61.5 % among them DM compensation was satisfactory (HbA1с level was 7.5–8.5 %), and in 38.5 % unsatisfactory (HbA1с level > 8.5 %). Negative correlation is set between the increase of HbA1с level and decline of 25(OH)D (r = –0.39, p < 0.05). Conclusions. The significant improvement of the state of type 2 diabetes mellitus compensation is set after the drug correction of vitamin D level.

Keywords

• type 2 diabetes mellitus
• vitamin D
• glycated hemoglobin
• glycemic control