Serum Neuron-specific Enolase and S100 Calcium-binding Protein B in Pediatric Diabetic Ketoacidosis
Hatem Hamed Elshorbagy,
Naglaa Fathy Barseem,
Akram Elshafey Elsadek,
Ashraf Hamed Al-shokary,
Yehia Hamed Abdel Maksoud,
Sameh Elsayed Abdulsamea,
Iman M. Talaat,
Hany Abdelaziz Suliman,
Naglaa M. Kamal,
Waleed E. Abdelghani,
Sanaa Mohammed Azab,
Dalia Mohamed Nour El Din
Affiliations
Hatem Hamed Elshorbagy
Menoufia University Faculty of Medicine, Departments of Pediatrics and Pediatric Neurology, Shebeen Elkom, Egypt; Alhada and Taif Armed forces Hospitals, Departments of Pediatrics and Pediatric Neurology, Taif, Saudi Arabia
Naglaa Fathy Barseem
Menofia University Faculty of Medicine, Department of Pediatrics, Shebeen Elkom, Egypt
Akram Elshafey Elsadek
Benha University Faculty of Medicine, Department of Pediatrics, Al Obour, Egypt
Ashraf Hamed Al-shokary
Benha University Faculty of Medicine, Department of Pediatrics, Al Obour, Egypt
Yehia Hamed Abdel Maksoud
Benha University Faculty of Medicine, Department of Pediatrics, Al Obour, Egypt
Sameh Elsayed Abdulsamea
Benha University Faculty of Medicine, Department of Pediatrics, Al Obour, Egypt
Iman M. Talaat
Ain Shams University Faculty of Medicine, Department of Pediatrics, Cairo, Egypt
Hany Abdelaziz Suliman
Benha University Faculty of Medicine, Department of Pediatrics, Al Obour, Egypt
Naglaa M. Kamal
Cairo University Faculty of Medicine, Departments of Pediatrics and Pediatric Hepatology, Cairo, Egypt; Alhada Armed forces Hospital, Clinics of Pediatric Hepatology and Gastroenterology, Taif, Saudi Arabia
Waleed E. Abdelghani
Benha University Faculty of Medicine, Department of Pediatrics, Al Obour, Egypt
Sanaa Mohammed Azab
Al-Azhar University Faculty of Medicine, Department of Pediatrics, El-Khalifa, Egypt
Dalia Mohamed Nour El Din
Benha University Faculty of Medicine, Department of Clinical Pathology, Benha, Egypt
Objective:Neuron-specific enolase (NSE) and S100 calcium-binding protein B (S100B) are markers of different neurological disorders. The aim was to investigate the relationship between NSE and S100B serum concentrations and the severity of diabetic ketoacidosis (DKA) in diabetic children.Methods:Eighty children with DKA, 40 with type 1 diabetes mellitus (T1DM) without DKA and 40 healthy controls were enrolled. Severity of DKA was assessed according to blood pH and bicarbonate concentration. Serum NSE and S100B were measured in all participants. In the DKA group serum NSE and S100B were measured at three time points, at admission and at 12 hours and 24 hours after starting treatment.Results:Children with DKA showed significantly higher serum levels of NSE at all time points compared to children with T1DM without DKA and controls (p0.05). Younger age, lower GCSS, higher glucose and HbA1c, lower pH and lower serum bicarbonate were the risk factors associated with elevated NSE.Conclusion:Serum NSE is elevated in all patients with type 1 DM and, in patients with DKA, correlates with severity of DKA. However, serum S100B concentration did not differ between T1DM with or without DKA and healthy controls.
