Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes

Calwing Liao; Alexandre D. Laporte; Dan Spiegelman; Fulya Akçimen; Ridha Joober; Patrick A. Dion; Guy A. Rouleau

doi:10.1038/s41467-019-12450-9

Nature Communications (Oct 2019)

Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes

Calwing Liao,
Alexandre D. Laporte,
Dan Spiegelman,
Fulya Akçimen,
Ridha Joober,
Patrick A. Dion,
Guy A. Rouleau

Affiliations

Calwing Liao: Department of Human Genetics, McGill University
Alexandre D. Laporte: Montreal Neurological Institute, McGill University
Dan Spiegelman: Montreal Neurological Institute, McGill University
Fulya Akçimen: Department of Human Genetics, McGill University
Ridha Joober: Department of Psychiatry, McGill University
Patrick A. Dion: Montreal Neurological Institute, McGill University
Guy A. Rouleau: Department of Human Genetics, McGill University

DOI: https://doi.org/10.1038/s41467-019-12450-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 7

Abstract

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A recent GWAS reported 12 genetic loci for attention deficit/hyperactivity disorder (ADHD). Here, Liao et al. perform transcriptomic imputation using these data and 12 brain-relevant tissues from GTEx and CMC to identify 9 genes associated with ADHD by TWAS, 3 of which had not yet been reported for ADHD.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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