Childhood nocturnal enuresis and clinical course of overactive bladder in women

Abstract

Background. Overactive bladder (OAB) and nocturnal enuresis are among the most common causes of urinary dysfunction in adults and children, respectively. The pathogenesis factors of OAB and nocturnal enuresis largely coincide. Among adults with OAB, a large proportion of patients have a history of nocturnal enuresis. Aim. To study the features of the clinical course of OAB in women with childhood nocturnal enuresis. Materials and methods. The study included 212 women with OAB (mean age 54.1±0.8 years), who were divided into two groups depending on the presence of the history of childhood nocturnal enuresis. Group 1 included 41 (19.3%) patients with childhood nocturnal enuresis, group 2 included 171 (80.7%) women without a history of childhood nocturnal enuresis. All patients underwent a comprehensive urodynamic study. Results. The severity of clinical symptoms of OAB did not differ between patients of groups 1 and 2. Predictors of a more severe clinical course of OAB and a greater likelihood of developing urge incontinence were the presence of a non-monosymptomatic form of enuresis and an age of cessation of enuresis of 10 years or older. Women from group 1 also showed a higher incidence of detrusor overactivity compared to group 2 (29.3% vs 10.5%). Conclusion. The results of the study indicate a connection between childhood nocturnal enuresis and the clinical course of OAB in adult women.

Keywords

• overactive bladder
• detrusor overactivity
• nocturnal enuresis
• urge incontinence