Nature Communications (May 2018)
Factor XIIIA—expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking
- Alessandro Porrello,
- Patrick L. Leslie,
- Emily B. Harrison,
- Balachandra K. Gorentla,
- Sravya Kattula,
- Subrata K. Ghosh,
- Salma H. Azam,
- Alisha Holtzhausen,
- Yvonne L. Chao,
- Michele C. Hayward,
- Trent A. Waugh,
- Sanggyu Bae,
- Virginia Godfrey,
- Scott H. Randell,
- Cecilia Oderup,
- Liza Makowski,
- Jared Weiss,
- Matthew D. Wilkerson,
- D. Neil Hayes,
- H. Shelton Earp,
- Albert S. Baldwin,
- Alisa S. Wolberg,
- Chad V. Pecot
Affiliations
- Alessandro Porrello
- UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Patrick L. Leslie
- UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Emily B. Harrison
- Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
- Balachandra K. Gorentla
- UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Sravya Kattula
- Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill
- Subrata K. Ghosh
- UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Salma H. Azam
- Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill
- Alisha Holtzhausen
- UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Yvonne L. Chao
- Division of Hematology & Oncology, University of North Carolina at Chapel Hill
- Michele C. Hayward
- UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Trent A. Waugh
- UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Sanggyu Bae
- Division of Hematology & Oncology, University of North Carolina at Chapel Hill
- Virginia Godfrey
- Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill
- Scott H. Randell
- Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill
- Cecilia Oderup
- Cancer Immunology, Pfizer, Inc
- Liza Makowski
- UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Jared Weiss
- UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Matthew D. Wilkerson
- Department of Anatomy, Physiology and Genetics, The American Genome Center, Collaborative Health Initiative Research Program, Uniformed Services University
- D. Neil Hayes
- UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- H. Shelton Earp
- UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Albert S. Baldwin
- UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Alisa S. Wolberg
- Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill
- Chad V. Pecot
- UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- DOI
- https://doi.org/10.1038/s41467-018-04355-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 19
Abstract
Lung squamous carcinomas (LUSC) are poorly molecularly characterized, but sub-populations show promising response to immune checkpoint inhibitors. Here, the authors identify a subset of LUSC characterized by infiltration of inflammatory monocytes, where metastasis is linked to Factor XIIIA promoting fibrin cross-linking.
