Short communication: carboxylate functionalized superparamagnetic iron oxide nanoparticles (SPION) for the reduction of S. aureus growth post biofilm formation

International Journal of Nanomedicine. 2013;2013(default):731-736


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Journal Title: International Journal of Nanomedicine

ISSN: 1176-9114 (Print); 1178-2013 (Online)

Publisher: Dove Medical Press

LCC Subject Category: Medicine: Medicine (General)

Country of publisher: United Kingdom

Language of fulltext: English



Leuba KD

Durmus NG

Taylor EN

Webster TJ



Abstract | Full Text

Kohana D Leuba, Naside Gozde Durmus, Erik N Taylor, Thomas J WebsterThe Nanomedicine Laboratory, School of Engineering, Brown University, Providence, RI, USAAbstract: Biofilms formed by antibiotic resistant Staphylococcus aureus (S. aureus) continue to be a problem for medical devices. Antibiotic resistant bacteria (such as S. aureus) often complicate the treatment and healing of the patient, yet, medical devices are needed to heal such patients. Therefore, methods to treat these biofilms once formed on medical devices are badly needed. Due to their small size and magnetic properties, superparamagnetic iron oxide nanoparticles (SPION) may be one possible material to penetrate biofilms and kill or slow the growth of bacteria. In this study, SPION were functionalized with amine, carboxylate, and isocyanate functional groups to further improve their efficacy to disrupt the growth of S. aureus biofilms. Without the use of antibiotics, results showed that SPION functionalized with carboxylate groups (followed by isocyanate then amine functional groups then unfunctionalized SPION) significantly disrupted biofilms and retarded the growth of S. aureus compared to untreated biofilms (by over 35% after 24 hours).Keywords: antibacterial, medical device infection, nanoparticle, iron oxide, biofilm, S. aureus