Co-variations of cerebral blood volume and single neurons discharge during resting state and visual cognitive tasks in non-human primates
Julien Claron,
Matthieu Provansal,
Quentin Salardaine,
Pierre Tissier,
Alexandre Dizeux,
Thomas Deffieux,
Serge Picaud,
Mickael Tanter,
Fabrice Arcizet,
Pierre Pouget
Affiliations
Julien Claron
Stem Cell and Brain Research Institute, INSERM U1208, Bron, France; Paris Brain Institute, Institut du Cerveau, INSERM 1127, CNRS 7225 Sorbonne Université, Paris, France
Matthieu Provansal
Institut de la Vision, CNRS, INSERM, Sorbonne Université, Paris, France
Quentin Salardaine
Paris Brain Institute, Institut du Cerveau, INSERM 1127, CNRS 7225 Sorbonne Université, Paris, France
Pierre Tissier
Paris Brain Institute, Institut du Cerveau, INSERM 1127, CNRS 7225 Sorbonne Université, Paris, France
Alexandre Dizeux
Physics for Medicine, ESPCI, INSERM, CNRS, PSL Research University, Paris, France
Thomas Deffieux
Physics for Medicine, ESPCI, INSERM, CNRS, PSL Research University, Paris, France
Serge Picaud
Institut de la Vision, CNRS, INSERM, Sorbonne Université, Paris, France
Mickael Tanter
Physics for Medicine, ESPCI, INSERM, CNRS, PSL Research University, Paris, France; Corresponding author
Fabrice Arcizet
Institut de la Vision, CNRS, INSERM, Sorbonne Université, Paris, France; Corresponding author
Pierre Pouget
Paris Brain Institute, Institut du Cerveau, INSERM 1127, CNRS 7225 Sorbonne Université, Paris, France; Corresponding author
Summary: To better understand how the brain allows primates to perform various sets of tasks, the ability to simultaneously record neural activity at multiple spatiotemporal scales is challenging but necessary. However, the contribution of single-unit activities (SUAs) to neurovascular activity remains to be fully understood. Here, we combine functional ultrasound imaging of cerebral blood volume (CBV) and SUA recordings in visual and fronto-medial cortices of behaving macaques. We show that SUA provides a significant estimate of the neurovascular response below the typical fMRI spatial resolution of 2mm3. Furthermore, our results also show that SUAs and CBV activities are statistically uncorrelated during the resting state but correlate during tasks. These results have important implications for interpreting functional imaging findings while one constructs inferences of SUA during resting state or tasks.
