Pharmaceuticals (Apr 2023)

An Insight into Advances in Developing Nanotechnology Based Therapeutics, Drug Delivery, Diagnostics and Vaccines: Multidimensional Applications in Tuberculosis Disease Management

  • Hitesh Chopra,
  • Yugal Kishore Mohanta,
  • Pradipta Ranjan Rauta,
  • Ramzan Ahmed,
  • Saurov Mahanta,
  • Piyush Kumar Mishra,
  • Paramjot Panda,
  • Ali A. Rabaan,
  • Ahmad A. Alshehri,
  • Basim Othman,
  • Mohammed Abdulrahman Alshahrani,
  • Ali S. Alqahtani,
  • Baneen Ali AL Basha,
  • Kuldeep Dhama

DOI
https://doi.org/10.3390/ph16040581
Journal volume & issue
Vol. 16, no. 4
p. 581

Abstract

Read online

Tuberculosis (TB), one of the deadliest contagious diseases, is a major concern worldwide. Long-term treatment, a high pill burden, limited compliance, and strict administration schedules are all variables that contribute to the development of MDR and XDR tuberculosis patients. The rise of multidrug-resistant strains and a scarcity of anti-TB medications pose a threat to TB control in the future. As a result, a strong and effective system is required to overcome technological limitations and improve the efficacy of therapeutic medications, which is still a huge problem for pharmacological technology. Nanotechnology offers an interesting opportunity for accurate identification of mycobacterial strains and improved medication treatment possibilities for tuberculosis. Nano medicine in tuberculosis is an emerging research field that provides the possibility of efficient medication delivery using nanoparticles and a decrease in drug dosages and adverse effects to boost patient compliance with therapy and recovery. Due to their fascinating characteristics, this strategy is useful in overcoming the abnormalities associated with traditional therapy and leads to some optimization of the therapeutic impact. It also decreases the dosing frequency and eliminates the problem of low compliance. To develop modern diagnosis techniques, upgraded treatment, and possible prevention of tuberculosis, the nanoparticle-based tests have demonstrated considerable advances. The literature search was conducted using Scopus, PubMed, Google Scholar, and Elsevier databases only. This article examines the possibility of employing nanotechnology for TB diagnosis, nanotechnology-based medicine delivery systems, and prevention for the successful elimination of TB illnesses.

Keywords