Insulin action and resistance are dependent on a GSK3β-FBXW7-ERRα transcriptional axis

Hui Xia; Charlotte Scholtes; Catherine R. Dufour; Carlo Ouellet; Majid Ghahremani; Vincent Giguère

doi:10.1038/s41467-022-29722-6

Nature Communications (Apr 2022)

Insulin action and resistance are dependent on a GSK3β-FBXW7-ERRα transcriptional axis

Hui Xia,
Charlotte Scholtes,
Catherine R. Dufour,
Carlo Ouellet,
Majid Ghahremani,
Vincent Giguère

Affiliations

Hui Xia: Rosalind and Morris Goodman Cancer Research Institute, McGill University
Charlotte Scholtes: Rosalind and Morris Goodman Cancer Research Institute, McGill University
Catherine R. Dufour: Rosalind and Morris Goodman Cancer Research Institute, McGill University
Carlo Ouellet: Rosalind and Morris Goodman Cancer Research Institute, McGill University
Majid Ghahremani: Rosalind and Morris Goodman Cancer Research Institute, McGill University
Vincent Giguère: Rosalind and Morris Goodman Cancer Research Institute, McGill University

DOI: https://doi.org/10.1038/s41467-022-29722-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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The downstream mechanisms involved in insulin signaling and resistance remain incompletely understood. Here the authors report that insulin-dependent dephosphorylation stabilizes ERRα via the GSK3β/FBXW7 axis, and disruption of this post-translational mechanism results in insulin resistance in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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