PLoS ONE (Jan 2021)

Right-ventricular mechanics assessed by cardiovascular magnetic resonance feature tracking in children with hypertrophic cardiomyopathy.

  • Joanna Petryka-Mazurkiewicz,
  • Lidia Ziolkowska,
  • Łukasz Mazurkiewicz,
  • Monika Kowalczyk-Domagała,
  • Agnieszka Boruc,
  • Mateusz Śpiewak,
  • Magdalena Marczak,
  • Grażyna Brzezinska-Rajszys

DOI
https://doi.org/10.1371/journal.pone.0248725
Journal volume & issue
Vol. 16, no. 3
p. e0248725

Abstract

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BackgroundAlthough hypertrophic cardiomyopathy (HCM) is considered a disease of the left ventricle (LV), right ventricular (RV) abnormalities have also been reported on. Cardiovascular magnetic resonance feature tracking (CMR-FT) accurately and reproducibly quantifies RV myocardial deformation.AimTo investigate RV deformation disorders in childhood HCM using CMR-FT.Material and methodsConsecutive subjects aged ResultsWe included 54 children (37 males, 68.5%) with HCM, of which 28 patients (51.8%; mean extent of 2.18 ± 2.34% of LV mass) had late gadolinium enhancement. LV outflow tract obstruction (LVOTO) was detected in 19 subjects (35.2%). In patients with LVOTO, RV global longitudinal strain (RVGLS) (-16.1±5.0 vs. -20.7±5.3, pConclusionsChildren with HCM, especially with LVOTO, have significantly reduced indices of RV mechanics despite normal RV systolic function. It seems that the degree of LVOT obstruction is responsible for compromising the RV dynamics, rather than either mass or the amount of LV fibrosis.