World Allergy Organization Journal (Jan 2022)
World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines update – I – Plan and definitions
- Alessandro Fiocchi, MD,
- Antonio Bognanni, MD,
- Jan Brożek, MD, PhD,
- Motohiro Ebisawa, MD, PhD,
- Holger Schünemann, MD,
- Ignacio J. Ansotegui, MD, PhD,
- Stefania Arasi, MD,
- Amal H. Assa'ad, MD,
- Sami L. Bahna, MD, DrPH,
- Roberto Berni Canani, MD, PhD,
- Martin Bozzola, MD,
- Derek Chu,
- Lamia Dahdah, MD,
- Christophe Dupont, MD, PhD,
- Ramon Targino Firmino,
- Elena Galli, MD, PhD,
- Rose Kamenwa, MD,
- Gideon Lack, MD,
- Haiqi Li, MD,
- Alberto Martelli, MD,
- Anna Nowak-Węgrzyn, MD,
- Nikolas G. Papadopoulos, MD, PhD,
- Ruby Pawankar, MD, PhD,
- Maria Said, RN,
- Mario Sánchez-Borges,
- Raanan Shamir, PhD,
- Jonathan M. Spergel, MD, PhD,
- Hania Szajewska, MD,
- Luigi Terracciano, MD,
- Yvan Vandenplas, MD, PhD,
- Carina Venter, PhD, RD,
- Amena Warner,
- Susan Waserman, MD, MSc,
- Gary W.K. Wong, MD
Affiliations
- Alessandro Fiocchi, MD
- Translational Research in Pediatric Specialities Area, Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; Corresponding author. Translational Research in Pediatric Specialities Area, Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio, 4, Rome 00165, Italy
- Antonio Bognanni, MD
- Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, ON, Canada
- Jan Brożek, MD, PhD
- Department of Medicine, Division of Clinical Immunology and Allergy, Department of Clinical Epidemiology & Biostatistics, McMaster University Health Sciences Centre, Hamilton, ON, Canada
- Motohiro Ebisawa, MD, PhD
- Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Kanagawa, Japan
- Holger Schünemann, MD
- Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, ON, Canada; Cochrane Canada and McMaster GRADE Centre, Hamilton, Ontario, Canada
- Ignacio J. Ansotegui, MD, PhD
- Department of Allergy & Immunology, Hospital Quironsalud Bizkaia, Erandio, Bilbao, Spain
- Stefania Arasi, MD
- Translational Research in Pediatric Specialities Area, Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, Erandio, Rome, Italy
- Amal H. Assa'ad, MD
- Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
- Sami L. Bahna, MD, DrPH
- Allergy/Immunology Section, Louisiana State University Health Sciences Center, Shreveport, LA, USA
- Roberto Berni Canani, MD, PhD
- Department of Translational Medical Science, University of Naples Federico II, Naples, Italy
- Martin Bozzola, MD
- Department of Pediatrics, Pediatric Allergy/Immunology Section, British Hospital, Buenos Aires, Argentina
- Derek Chu
- Paris Descartes University, Pediatric Gastroenterology, Necker Hospital, Paris, Clinique Marcel Sembat, Boulogne-Billancourt, France
- Lamia Dahdah, MD
- Translational Research in Pediatric Specialities Area, Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, Erandio, Rome, Italy
- Christophe Dupont, MD, PhD
- Department of Medicine, Division of Clinical Immunology and Allergy, Department of Clinical Epidemiology & Biostatistics, McMaster University Health Sciences Centre, Erandio, Hamilton, ON, Canada
- Ramon Targino Firmino
- Faculty of Medical Sciences of Campina Grande, UNIFACISA University Centre, Campina Grande, Paraiba, Brazil
- Elena Galli, MD, PhD
- Pediatric Allergy Unit, Research Center, San Pietro-Fatebenefratelli Hospital, Rome, Italy
- Rose Kamenwa, MD
- Department of Pediatrics and Child Health, Aga Khan University Hospital, Nairobi, Kenya
- Gideon Lack, MD
- Department of Women and Children's Health/Peter Gorer Department of Immunobiology, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King's College London, UK; Evelina London Children's Hospital, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK
- Haiqi Li, MD
- Pediatric Division Department of Primary Child Care, Children's Hospital, Chongqing Medical University, Chongqing, China
- Alberto Martelli, MD
- Italian Society of Pediatric Allergy and Immunology, Milano, Italy
- Anna Nowak-Węgrzyn, MD
- Department of Pediatrics, New York University Langone Health, New York, NY, USA; Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland
- Nikolas G. Papadopoulos, MD, PhD
- Allergy Unit, 2nd Pediatric Clinic, University of Athens, Athens, Greece; Division of Infection, Immunity & Respiratory Medicine, University of Manchester, UK
- Ruby Pawankar, MD, PhD
- Department of Pediatrics, Nippon Medical School, Bunkyo-Ku, Tokyo, Japan
- Maria Said, RN
- Allergy & Anaphylaxis Australia (A&AA), Castle Hills, New South Wales, Australia
- Mario Sánchez-Borges
- Department of Allergy and Clinical Immunology, Centro Médico-Docente La Trinidad Caracas, Venezuela
- Raanan Shamir, PhD
- Institute of Gastroenterology, Nutrition and Liver Disease, Schneider Children's Medical Center, Petach-Tikva, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
- Jonathan M. Spergel, MD, PhD
- Division of Allergy and Immunology, Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA
- Hania Szajewska, MD
- The Medical University of Warsaw - Department of Paediatrics, Warsaw, Poland
- Luigi Terracciano, MD
- Italian NHS and Italian Society of Social and Preventive Pediatrics, Milano, Italy
- Yvan Vandenplas, MD, PhD
- Department of Pediatrics, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium
- Carina Venter, PhD, RD
- Section of Allergy & Immunology, University of Colorado Denver School of Medicine, Children's Hospital Colorado, Aurora, CO, USA
- Amena Warner
- Allergy UK, Planwell House, Sidcup, Kent, UK
- Susan Waserman, MD, MSc
- Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, ON, Canada
- Gary W.K. Wong, MD
- Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
- Journal volume & issue
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Vol. 15,
no. 1
p. 100609
Abstract
Since the World Allergy Organization (WAO) Diagnosis and Rationale against Cow's Milk Allergy (DRACMA) Guidelines were published 10 years ago, new evidence has accumulated about the diagnosis, therapy, and specific immunotherapy for cow's milk allergy (CMA). For this reason, WAO has felt the need to update the guidelines.We introduce here this update. The new DRACMA guidelines aim to comprehensively address the guidance on diagnosis and therapy of both IgE non-IgE-mediated forms of cow's milk allergy in children and adults. They will be divided into 18 chapters, each of which will be dedicated to an aspect. The focus will be on the meta-analyzes and recommendations that will be expressed for the 3 most relevant clinical aspects: (a) the diagnostic identification of the condition; (b) the choice of the replacement formula in case of CMA in infancy when the mother is not able to breastfeed, and (c) the use of specific immunotherapy for cow's milk protein allergy.
