Cucurbit[n]uril-based fluorescent indicator-displacement assays for sensing organic compounds

Qunpeng Duan; Ran Chen; Su Deng; Cheng Yang; Xinxin Ji; Gege Qi; Hui Li; Xiaohan Li; Shihao Chen; Mengen Lou; Kui Lu; Kui Lu

doi:10.3389/fchem.2023.1124705

Frontiers in Chemistry (Jan 2023)

Cucurbit[n]uril-based fluorescent indicator-displacement assays for sensing organic compounds

Qunpeng Duan,
Ran Chen,
Su Deng,
Cheng Yang,
Xinxin Ji,
Gege Qi,
Hui Li,
Xiaohan Li,
Shihao Chen,
Mengen Lou,
Kui Lu,
Kui Lu

Affiliations

Qunpeng Duan: School of Chemical and Printing-Dyeing Engineering, Henan University of Engineering, Zhengzhou, China
Ran Chen: School of Chemical and Printing-Dyeing Engineering, Henan University of Engineering, Zhengzhou, China
Su Deng: School of Chemical and Printing-Dyeing Engineering, Henan University of Engineering, Zhengzhou, China
Cheng Yang: School of Chemical and Printing-Dyeing Engineering, Henan University of Engineering, Zhengzhou, China
Xinxin Ji: School of Chemical and Printing-Dyeing Engineering, Henan University of Engineering, Zhengzhou, China
Gege Qi: School of Chemical and Printing-Dyeing Engineering, Henan University of Engineering, Zhengzhou, China
Hui Li: School of Chemical and Printing-Dyeing Engineering, Henan University of Engineering, Zhengzhou, China
Xiaohan Li: School of Chemical and Printing-Dyeing Engineering, Henan University of Engineering, Zhengzhou, China
Shihao Chen: School of Chemical and Printing-Dyeing Engineering, Henan University of Engineering, Zhengzhou, China
Mengen Lou: School of Chemical and Printing-Dyeing Engineering, Henan University of Engineering, Zhengzhou, China
Kui Lu: School of Chemical and Printing-Dyeing Engineering, Henan University of Engineering, Zhengzhou, China
Kui Lu: School of Chemical Engineering and Food Science, Zhengzhou Institute of Technology, Zhengzhou, China

DOI: https://doi.org/10.3389/fchem.2023.1124705
Journal volume & issue: Vol. 11

Abstract

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The widespread conversion of synthetic receptors into luminescent sensors has been achieved via the use of fluorescent-indicator displacement assays (F-IDAs). Due to their rigid structures and efficient binding affinities, cucurbit[n]urils, combined with a variety of fluorescent guests, have gained extensive utilization in fluorescent-indicator displacement assays for sensing non-fluorescent or weakly fluorescent organic compounds (analytes) in a selective and specific manner. This mini-review summarizes recent advances in the design of cucurbit[n]uril-based fluorescent-indicator displacement assays and discusses the current challenges and future prospects in this area.

Published in Frontiers in Chemistry

ISSN: 2296-2646 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://journal.frontiersin.org/journal/chemistry

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