Медицинская иммунология (Jul 2014)

ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS

  • A. V. Tsybulsky,
  • A. M. Popov,
  • O. Yu. Portnyagina,
  • A. A. Artyukov,
  • N. M. Sanina,
  • A. N. Mazeyka,
  • E. Y. Kostetsky

DOI
https://doi.org/10.15789/1563-0625-2011-2-3-139-144
Journal volume & issue
Vol. 13, no. 2-3
pp. 139 – 144

Abstract

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Abstract. We investigated immunogenic properties of vaccine constructs based on lipid-saponin tubular immunostimulating complexes (TI-complexes), and an individual antigen, i.e., monomeric and trimeric forms of porin isolated from Yersinia pseudotuberculosis. An opportunity of enhanced immune response to TI-embedded porin was shown upon addition of echinochrome A (ECA) from sea urchin Scaphechinus mirabilis to TI-complexes. Immunization of mice with such a vaccine preparation results into a more intense specific humoral immune response to monomeric and trimeric forms of porin. (Med. Immunol., 2011, vol. 13, N 2-3, pp 139-144)

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