Journal of Community Hospital Internal Medicine Perspectives (Apr 2016)

Calcitriol-mediated hypercalcemia in a patient with bilateral adrenal non-Hodgkin's B-cell lymphoma case report

  • Ana Abaroa-Salvatierra,
  • Bilal Shaikh,
  • Mrunalini Deshmukh,
  • Richard Alweis,
  • Arti Patel

DOI
https://doi.org/10.3402/jchimp.v6.30381
Journal volume & issue
Vol. 6, no. 2
pp. 1 – 3

Abstract

Read online

Calcitriol-mediated hypercalcemia is a frequent manifestation of hematological malignancies. However, there are a few reports of cases presenting with increased angiotensin-converting enzyme (ACE) level, which suggests a possible mechanism similar to that of granulomatous diseases. We present a patient with hypercalcemia, normal parathyroid hormone, and parathyroid hormone-related protein levels but high calcitriol and ACE levels that, after further investigation, was diagnosed with bilateral adrenal non-Hodgkin's B-cell lymphoma. Primary adrenal lymphoma represents only 1% of all non-Hodgkin's lymphomas and is usually asymptomatic but should be considered by clinicians among the malignancies that cause calcitriol-mediated hypercalcemia.

Keywords