Study of the effects of nitroquinoline derivatives on Neisseria gonorrhoeae causative agent of the sexually transmitted infection gonorrhea

Aisha Khalil; Atia-tul-Wahab; Sara Shafi; Saba Farooq; Hina Siddiqui; M. Iqbal Choudhary

Results in Chemistry (Jan 2024)

Study of the effects of nitroquinoline derivatives on Neisseria gonorrhoeae causative agent of the sexually transmitted infection gonorrhea

Aisha Khalil,
Atia-tul-Wahab,
Sara Shafi,
Saba Farooq,
Hina Siddiqui,
M. Iqbal Choudhary

Affiliations

Aisha Khalil: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
Atia-tul-Wahab: Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center of Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Corresponding authors at: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan (M. Iqbal Choudhary).
Sara Shafi: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
Saba Farooq: Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center of Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
Hina Siddiqui: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
M. Iqbal Choudhary: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center of Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Corresponding authors at: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan (M. Iqbal Choudhary).

Journal volume & issue: Vol. 7
p. 101481

Abstract

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According to the World Health Organization (WHO), sexually transmitted infection (SI) gonorrhea is now a global public health challenge due to failure of current treatments. Therefore, it is important to develop new agents against drug-resistant N. gonorrhoeae, the causative agent of gonorrhea infection.The aim of the present research was to identify active compounds against STI causing bacteria N. gonorrhoeae, and to investigate their modes of action. Alamar blue assay was used to evaluate the antibacterial activity. Compound-induced alterations were investigated by atomic force and scanning electron microscopies. MICs of nitroquinoline derivatives 5 and 8 were 302.8 and 193.23 µM (54.99, and 49.99 µg/mL, respectively), lower than the MIC of the first line of standard drug, ceftriaxone 450.79 µM ± 1.8 (249.99 µg/mL). Cytotoxicity of compounds were also evaluated in blood media. Nitroquinoline derivatives 5 and 8 were found to be more potent than currently used antibiotics, and thus deserve further investigation.

Published in Results in Chemistry

ISSN: 2211-7156 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: https://www.journals.elsevier.com/results-in-chemistry/

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