Nature Communications (May 2020)
Protein-altering germline mutations implicate novel genes related to lung cancer development
- Xuemei Ji,
- Semanti Mukherjee,
- Maria Teresa Landi,
- Yohan Bosse,
- Philippe Joubert,
- Dakai Zhu,
- Ivan Gorlov,
- Xiangjun Xiao,
- Younghun Han,
- Olga Gorlova,
- Rayjean J. Hung,
- Yonathan Brhane,
- Robert Carreras-Torres,
- David C. Christiani,
- Neil Caporaso,
- Mattias Johansson,
- Geoffrey Liu,
- Stig E. Bojesen,
- Loic Le Marchand,
- Demetrios Albanes,
- Heike Bickeböller,
- Melinda C. Aldrich,
- William S. Bush,
- Adonina Tardon,
- Gad Rennert,
- Chu Chen,
- Jinyoung Byun,
- Konstantin H. Dragnev,
- John K. Field,
- Lambertus FA. Kiemeney,
- Philip Lazarus,
- Shan Zienolddiny,
- Stephen Lam,
- Matthew B. Schabath,
- Angeline S. Andrew,
- Pier A. Bertazzi,
- Angela C. Pesatori,
- Nancy Diao,
- Li Su,
- Lei Song,
- Ruyang Zhang,
- Natasha Leighl,
- Jakob S. Johansen,
- Anders Mellemgaard,
- Walid Saliba,
- Christopher Haiman,
- Lynne Wilkens,
- Ana Fernandez-Somoano,
- Guillermo Fernandez-Tardon,
- Erik H. F. M. van der Heijden,
- Jin Hee Kim,
- Michael P. A. Davies,
- Michael W. Marcus,
- Hans Brunnström,
- Jonas Manjer,
- Olle Melander,
- David C. Muller,
- Kim Overvad,
- Antonia Trichopoulou,
- Rosario Tumino,
- Gary E. Goodman,
- Angela Cox,
- Fiona Taylor,
- Penella Woll,
- Erich Wichmann,
- Thomas Muley,
- Angela Risch,
- Albert Rosenberger,
- Kjell Grankvist,
- Mikael Johansson,
- Frances Shepherd,
- Ming-Sound Tsao,
- Susanne M. Arnold,
- Eric B. Haura,
- Ciprian Bolca,
- Ivana Holcatova,
- Vladimir Janout,
- Milica Kontic,
- Jolanta Lissowska,
- Anush Mukeria,
- Simona Ognjanovic,
- Tadeusz M. Orlowski,
- Ghislaine Scelo,
- Beata Swiatkowska,
- David Zaridze,
- Per Bakke,
- Vidar Skaug,
- Lesley M. Butler,
- Kenneth Offit,
- Preethi Srinivasan,
- Chaitanya Bandlamudi,
- Matthew D. Hellmann,
- David B. Solit,
- Mark E. Robson,
- Charles M. Rudin,
- Zsofia K. Stadler,
- Barry S. Taylor,
- Michael F. Berger,
- Richard Houlston,
- John McLaughlin,
- Victoria Stevens,
- David C. Nickle,
- Ma’en Obeidat,
- Wim Timens,
- María Soler Artigas,
- Sanjay Shete,
- Hermann Brenner,
- Stephen Chanock,
- Paul Brennan,
- James D. McKay,
- Christopher I. Amos
Affiliations
- Xuemei Ji
- Biomedical Data Science, Geisel School of Medicine at Dartmouth
- Semanti Mukherjee
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Maria Teresa Landi
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Yohan Bosse
- Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University
- Philippe Joubert
- Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University
- Dakai Zhu
- Biomedical Data Science, Geisel School of Medicine at Dartmouth
- Ivan Gorlov
- Biomedical Data Science, Geisel School of Medicine at Dartmouth
- Xiangjun Xiao
- The Institute for Clinical and Translational Research, Baylor College of Medicine
- Younghun Han
- The Institute for Clinical and Translational Research, Baylor College of Medicine
- Olga Gorlova
- Biomedical Data Science, Geisel School of Medicine at Dartmouth
- Rayjean J. Hung
- Lunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto
- Yonathan Brhane
- Lunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto
- Robert Carreras-Torres
- International Agency for Research on Cancer, World Health Organization
- David C. Christiani
- Department of Environmental Health, Harvard T.H. Chan School of Public Health
- Neil Caporaso
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Mattias Johansson
- International Agency for Research on Cancer, World Health Organization
- Geoffrey Liu
- Lunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto
- Stig E. Bojesen
- Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital
- Loic Le Marchand
- Epidemiology Program, University of Hawaii Cancer Center
- Demetrios Albanes
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Heike Bickeböller
- Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen
- Melinda C. Aldrich
- Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center
- William S. Bush
- Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University
- Adonina Tardon
- IUOPA. University of Oviedo and CIBERESP, Faculty of Medicine, Campus del Cristo s/n
- Gad Rennert
- Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine
- Chu Chen
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center
- Jinyoung Byun
- The Institute for Clinical and Translational Research, Baylor College of Medicine
- Konstantin H. Dragnev
- The Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center
- John K. Field
- Roy Castle lung Cancer Research Programme, Institute of Translational Medicine, University of Liverpool
- Lambertus FA. Kiemeney
- Radboud University Medical Center, Radboud Institute for Health Sciences
- Philip Lazarus
- Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University
- Shan Zienolddiny
- National Institute of Occupational Health
- Stephen Lam
- British Columbia Cancer Agency
- Matthew B. Schabath
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute
- Angeline S. Andrew
- Department of Epidemiology, Geisel School of Medicine
- Pier A. Bertazzi
- Department of Preventive Medicine, IRCCS Foundation Ca’ Granda Ospedale Maggiore Policlinico
- Angela C. Pesatori
- Department of Preventive Medicine, IRCCS Foundation Ca’ Granda Ospedale Maggiore Policlinico
- Nancy Diao
- Department of Environmental Health, Harvard T.H. Chan School of Public Health
- Li Su
- Department of Environmental Health, Harvard T.H. Chan School of Public Health
- Lei Song
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Ruyang Zhang
- Department of Environmental Health, Harvard T.H. Chan School of Public Health
- Natasha Leighl
- University Health Network- The Princess Margaret Cancer Centre
- Jakob S. Johansen
- Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital
- Anders Mellemgaard
- Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital
- Walid Saliba
- Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine
- Christopher Haiman
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
- Lynne Wilkens
- Epidemiology Program, University of Hawaii Cancer Center
- Ana Fernandez-Somoano
- IUOPA. University of Oviedo and CIBERESP, Faculty of Medicine, Campus del Cristo s/n
- Guillermo Fernandez-Tardon
- IUOPA. University of Oviedo and CIBERESP, Faculty of Medicine, Campus del Cristo s/n
- Erik H. F. M. van der Heijden
- Radboud University Medical Center, Radboud Institute for Health Sciences
- Jin Hee Kim
- Department of Integrative Bioscience & Biotechnology, Sejong University
- Michael P. A. Davies
- Roy Castle lung Cancer Research Programme, Institute of Translational Medicine, University of Liverpool
- Michael W. Marcus
- Roy Castle lung Cancer Research Programme, Institute of Translational Medicine, University of Liverpool
- Hans Brunnström
- Department of Pathology, Lund University
- Jonas Manjer
- Faculty of Medicine, Lund University
- Olle Melander
- Faculty of Medicine, Lund University
- David C. Muller
- School of Public Health, St Mary’s Campus, Imperial College London
- Kim Overvad
- Faculty of Medicine, Lund University
- Antonia Trichopoulou
- Hellenic Health Foundation
- Rosario Tumino
- Cancer Registry and Histopathology Department, “Civic - M.P. Arezzo” Hospital
- Gary E. Goodman
- Fred Hutchinson Cancer Research Center
- Angela Cox
- Department of Oncology and Metabolism, University of Sheffield
- Fiona Taylor
- Department of Oncology and Metabolism, University of Sheffield
- Penella Woll
- Department of Oncology and Metabolism, University of Sheffield
- Erich Wichmann
- Research Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
- Thomas Muley
- Thoraxklinik at University Hospital Heidelberg
- Angela Risch
- University of Salzburg and Cancer Cluster Salzburg
- Albert Rosenberger
- Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen
- Kjell Grankvist
- Department of Medical Biosciences, Umeå University
- Mikael Johansson
- Department of Radiation Sciences, Umeå University
- Frances Shepherd
- Princess Margaret Cancer Centre
- Ming-Sound Tsao
- Princess Margaret Cancer Centre
- Susanne M. Arnold
- University of Kentucky, Markey Cancer Center
- Eric B. Haura
- Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute
- Ciprian Bolca
- Institute of Pneumology “Marius Nasta”
- Ivana Holcatova
- Charles University, 1st Faculty of Medicine
- Vladimir Janout
- Faculty of Health Sciences, Palacky University
- Milica Kontic
- Clinical Center of Serbia, Clinic for Pulmonology, School of Medicine, University of Belgrade
- Jolanta Lissowska
- Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Institute – Oncology Center
- Anush Mukeria
- Department of Epidemiology and Prevention, Russian N.N.Blokhin Cancer Research Centre
- Simona Ognjanovic
- International Organization for Cancer Prevention and Research
- Tadeusz M. Orlowski
- Department of Surgery, National Tuberculosis and Lung Diseases Research Institute
- Ghislaine Scelo
- International Agency for Research on Cancer, World Health Organization
- Beata Swiatkowska
- Nofer Institute of Occupational Medicine, Department of Environmental Epidemiology
- David Zaridze
- Department of Epidemiology and Prevention, Russian N.N.Blokhin Cancer Research Centre
- Per Bakke
- Department of Clinical Science, University of Bergen
- Vidar Skaug
- National Institute of Occupational Health
- Lesley M. Butler
- University of Pittsburgh Cancer Institute
- Kenneth Offit
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Preethi Srinivasan
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Chaitanya Bandlamudi
- Marie-Josée and Henry R. KravisCenter for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Matthew D. Hellmann
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- David B. Solit
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Mark E. Robson
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Charles M. Rudin
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Zsofia K. Stadler
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Barry S. Taylor
- Marie-Josée and Henry R. KravisCenter for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Michael F. Berger
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Richard Houlston
- The Institute of Cancer Research
- John McLaughlin
- University of Toronto
- Victoria Stevens
- American Cancer Society, Inc.
- David C. Nickle
- Merck Research Laboratories, Genetics and Pharmacogenomics
- Ma’en Obeidat
- The University of British Columbia Centre for Heart Lung Innovation, St Paul’s Hospital
- Wim Timens
- University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, GRIAC research institute
- María Soler Artigas
- Genetic Epidemiology Group, Department of Health Sciences, University of Leicester
- Sanjay Shete
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Hermann Brenner
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Stephen Chanock
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Paul Brennan
- International Agency for Research on Cancer, World Health Organization
- James D. McKay
- International Agency for Research on Cancer, World Health Organization
- Christopher I. Amos
- The Institute for Clinical and Translational Research, Baylor College of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-15905-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
In lung cancer, relatively few germline mutations are known to impact risk. Here the authors looked at rare variants in 39,146 individuals and find novel germline mutations associated with risk, as well as implicating ATM and a new candidate gene for lung cancer risk.
