Nature Communications (May 2022)
Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients
- Pere Millat-Martinez,
- Arvind Gharbharan,
- Andrea Alemany,
- Casper Rokx,
- Corine Geurtsvankessel,
- Grigorios Papageourgiou,
- Nan van Geloven,
- Carlijn Jordans,
- Geert Groeneveld,
- Francis Swaneveld,
- Ellen van der Schoot,
- Marc Corbacho-Monné,
- Dan Ouchi,
- Francini Piccolo Ferreira,
- Pierre Malchair,
- Sebastian Videla,
- Vanesa García García,
- Anna Ruiz-Comellas,
- Anna Ramírez-Morros,
- Joana Rodriguez Codina,
- Rosa Amado Simon,
- Joan-Ramon Grifols,
- Julian Blanco,
- Ignacio Blanco,
- Jordi Ara,
- Quique Bassat,
- Bonaventura Clotet,
- Bàrbara Baro,
- Andrea Troxel,
- Jaap Jan Zwaginga,
- Oriol Mitjà,
- Bart J. A. Rijnders,
- CoV-Early study group,
- COnV-ert study group
Affiliations
- Pere Millat-Martinez
- Fight AIDS and Infectious Diseases Foundation
- Arvind Gharbharan
- Department of Internal Medicine, Section of Infectious Diseases and department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center
- Andrea Alemany
- Fight AIDS and Infectious Diseases Foundation
- Casper Rokx
- Department of Internal Medicine, Section of Infectious Diseases and department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center
- Corine Geurtsvankessel
- Department of Viroscience, Erasmus MC
- Grigorios Papageourgiou
- Department of Biostatistics, Erasmus MC, University Medical Center
- Nan van Geloven
- Department of Biomedical Data Sciences, Section of Medical Statistics, Leiden University Medical Center
- Carlijn Jordans
- Department of Internal Medicine, Section of Infectious Diseases and department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center
- Geert Groeneveld
- Department of Infectious Diseases and Acute Internal Medicine, Leiden University Medical Center
- Francis Swaneveld
- Unit of Transfusion Medicine, Sanquin Blood Supply
- Ellen van der Schoot
- Department of Experimental Immunohematology, Sanquin Research
- Marc Corbacho-Monné
- Fight AIDS and Infectious Diseases Foundation
- Dan Ouchi
- Fight AIDS and Infectious Diseases Foundation
- Francini Piccolo Ferreira
- Bioclever-CRO
- Pierre Malchair
- Emergency Department, Bellvitge University Hospital, L’Hospitalet de LLobregat
- Sebastian Videla
- Fight AIDS and Infectious Diseases Foundation
- Vanesa García García
- Emergency Department, Bellvitge University Hospital, L’Hospitalet de LLobregat
- Anna Ruiz-Comellas
- Unitat de Suport a la Recerca de la Catalunya Central, Fundació Institut Universitari per a la recerca a l’Atenció Primària de Salut Jordi Gol i Gurina
- Anna Ramírez-Morros
- Unitat de Suport a la Recerca de la Catalunya Central, Fundació Institut Universitari per a la recerca a l’Atenció Primària de Salut Jordi Gol i Gurina
- Joana Rodriguez Codina
- Salut Catalunya Central, Hospital de Berga
- Rosa Amado Simon
- Salut Catalunya Central, Hospital de Berga
- Joan-Ramon Grifols
- Hospital Universitari Germans Trias i Pujol
- Julian Blanco
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP)
- Ignacio Blanco
- Hospital Universitari Germans Trias i Pujol
- Jordi Ara
- Hospital Universitari Germans Trias i Pujol
- Quique Bassat
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Bonaventura Clotet
- Fight AIDS and Infectious Diseases Foundation
- Bàrbara Baro
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Andrea Troxel
- Department of Population Health, NYU Grossman School of Medicine
- Jaap Jan Zwaginga
- Department of Haematology, Leiden University Medical Centre
- Oriol Mitjà
- Fight AIDS and Infectious Diseases Foundation
- Bart J. A. Rijnders
- Department of Internal Medicine, Section of Infectious Diseases and department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center
- CoV-Early study group
- COnV-ert study group
- DOI
- https://doi.org/10.1038/s41467-022-29911-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 9
Abstract
Clinical studies have suggested that the therapeutic potential of polyclonal convalescent plasma is highest in the first days of symptoms. Here, the authors present results from a pooled analysis of two clinical trials in COVID-19 outpatients that did not provide conclusive evidence in favor of convalescent plasma.
