The prognostic value of postoperative blood glucose in non-diabetic patients with rheumatic heart disease

Abstract

Abstract Background Blood glucose (BG) is a risk factor of adverse prognosis in non-diabetic patients in several conditions. However, a limited number of studies were performed to explore the relationship between postoperative BG and adverse outcomes in non-diabetic patients with rheumatic heart disease (RHD). Methods We identified 1395 non-diabetic patients who diagnosed with having RHD, and underwent at least one valve replacement and preoperative coronary angiography. BG was measured at admission to the intensive care unit (ICU) after surgery. The association of postoperative BG level with in-hospital and one-year mortality was accordingly analyzed. Results Included patients were stratified into four groups according to postoperative BG level’s (mmol/L) quartiles: Q1 ( 13.0 mmol/L was the best threshold for predicting in-hospital death (area under the curve (AUC) = 0.707, 95% confidence interval (CI): 0.634–0.780, P 13.0 mmol/L was an independent predictor of in-hospital mortality (adjusted odds ratio (OR) = 3.418, 95% CI: 1.713–6.821, P 13.2 (log-rank = 32.762, P < 0.001). Conclusion Postoperative BG, as a routine test, could be served as a risk measure for non-diabetic patients with RHD.

Keywords

• Rheumatic heart disease
• Valve replacement surgery
• Blood glucose
• In-hospital death