GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers

Yapeng Li; Junfeng Gao; Mohammad Kamran; Laura Harmacek; Thomas Danhorn; Sonia M. Leach; Brian P. O’Connor; James R. Hagman; Hua Huang

doi:10.1038/s41467-020-20766-0

Nature Communications (Jan 2021)

GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers

Yapeng Li,
Junfeng Gao,
Mohammad Kamran,
Laura Harmacek,
Thomas Danhorn,
Sonia M. Leach,
Brian P. O’Connor,
James R. Hagman,
Hua Huang

Affiliations

Yapeng Li: Department of Immunology and Genomic Medicine, National Jewish Health
Junfeng Gao: Department of Immunology and Genomic Medicine, National Jewish Health
Mohammad Kamran: Department of Immunology and Genomic Medicine, National Jewish Health
Laura Harmacek: Center for Genes, Environment and Health, National Jewish Health
Thomas Danhorn: Center for Genes, Environment and Health, National Jewish Health
Sonia M. Leach: Department of Immunology and Genomic Medicine, National Jewish Health
Brian P. O’Connor: Center for Genes, Environment and Health, National Jewish Health
James R. Hagman: Department of Immunology and Genomic Medicine, National Jewish Health
Hua Huang: Department of Immunology and Genomic Medicine, National Jewish Health

DOI: https://doi.org/10.1038/s41467-020-20766-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Mast cells are critical effectors of allergic inflammation and protection against parasitic infections. Here the authors demonstrate that GATA2 promotes chromatin accessibility at the super-enhancers of mast cell identity genes and primes both typical and super-enhancers at genes that respond to antigenic stimulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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