Nature Communications (Apr 2016)

The cell adhesion molecule Fasciclin2 regulates brush border length and organization in Drosophila renal tubules

  • Kenneth A. Halberg,
  • Stephanie M. Rainey,
  • Iben R. Veland,
  • Helen Neuert,
  • Anthony J. Dornan,
  • Christian Klämbt,
  • Shireen-Anne Davies,
  • Julian A. T. Dow

DOI
https://doi.org/10.1038/ncomms11266
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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In Drosophila, Fasciclin 2 (Fas2) has been mainly studied in the nervous system, yet this adhesion protein is more abundant in the adult renal tubule. Here the authors show that Fas2 is essential for brush border maintenance in renal tubules through regulation of microvilli length and organization.