THE ASSESSMENT OF SERUM AND GCF PROINFLAMMATORY CYTOKINES LEVELS IN PATIENTS WITH OSTEOPOROSIS AND PERIODONTAL DISEASE

Abstract

Chronic periodontitis is related to osteoporosis; TNFα has a potent resorbing activity on bone level, which affects the periodontal status. Aim of the study We proposed an evaluation of TNFα serum and gingival crevicular fluid levels in patients with osteoporosis and periodontal disease. Material and methods We assessed 64 patients, divided in two groups: osteoporotic patients and systemically healthy subjects. The patients were clinically examined and TNFα levels were measured in GCF and serum samples by ELISA methods. Results The clinical parameters presented higher values in the study group; also, TNFα levels were significantly elevated for the osteoporosis patients. Discussions It may be suggested that elevated GCF and serum TNFα contributes to high number of B cells and T cells present in the inflammatory periodontal tissues, enhancing the periodontal tissue breakdown. Conclusions The osteoporosis patients are prone to overproduce TNFα, which also activates the B cells and promotes the B cells activity in the periodontal inflammatory sites, aggravating the evolution of the periodontal disease.

Keywords

• TNFα
• osteoporosis
• periodontal status
• inflammation