International Journal of Infectious Diseases (Sep 2024)
Coxsackievirus A24 causing acute conjunctivitis in a 2023 outbreak in Vietnam
- Huy Tran,
- Thao Ha,
- Linh Hoang,
- Yen Tran,
- Kevin Ruder,
- Lina Zhong,
- Cindi Chen,
- YuHeng Liu,
- Danny Yu,
- Thomas Abraham,
- Armin Hinterwirth,
- Michael Deiner,
- Travis C. Porco,
- Thomas M. Lietman,
- Thuy Doan,
- Gerami D. Seitzman,
- Lalitha Prajna,
- N. Venkatesh Prajna,
- Ramesh Gunasekaran,
- Sankalp Singh Sharma,
- Vishnu Teja,
- Meenu Chaudhary,
- Sanjeeta Sitaula,
- Ali Sié,
- Boubacar Coulibaly,
- Mamadou Bountogo,
- Thanapong Somkijrungroj,
- Vannarut Satitpitakul,
- Huy Tran,
- Linh Hoàng Mai,
- Thảo Hạ Xuân,
- Yen Tran,
- Cristhian A. Urzua,
- Fabian Vega,
- Felipe Salgado,
- Loreto Cuitino,
- Fernando Pérez Pérez,
- Jaime Macías Martínez,
- Van Charles Lansingh,
- Sukhumal Thanapaisal,
- Wipada Laovirojjanakul,
- George McKie, Program Officer,
- Kenia Chavez,
- Travis Redd,
- Winston Chamberlain,
- Angel Cheng,
- Vivien Tham,
- Wiwan Sansanayudh,
- Abba Kaka Hajia Yakoura,
- Abdou Amza,
- Abdoul Salam Youssoufou Souley,
- Adam Nouhou Diori,
- Beido Nassirou,
- Boubacar Kadri,
- Boubacar Mariama,
- Cissé Mamadou Ibrahim,
- Lamyne Aboubacar Roufaye,
- Ramatou Boulhassane,
- Saley Ali,
- Zakou Abdou,
- Lee Goren,
- Irit Bahar,
- Ruti Sella,
- Clare Kelliher,
- Laura Green,
- Hon Shing Ong,
- Jod Mehta,
- Yu-Chi Liu,
- Benjamin A. Pinsky,
- De-Kuang Hwang,
- Nai-Wen Fan,
- Hong Sheng Chiong,
- Javier Lacorzana,
- Maria Cabrera-Aguas,
- Stephanie Watson,
- Edmund Tsui,
- Nina M. Cherian,
- Rachel Feit-Leichman,
- Reginald E. Hughes, Jr,
- Tania Onclinx,
- Joseph K Privratsky,
- Carol Yu,
- Esmeralda McClean,
- Iliana Molina,
- Armin Hinterwirth,
- Cindi Chen,
- Danny Yu,
- David Liu,
- Elodie Lebas,
- Emily Colby,
- Gerami Seitzman,
- Kevin Ruder,
- Lina Zhong,
- Michael Deiner,
- Thomas Abraham,
- Thomas Lietman,
- Thuy Doan, Principal Investigator,
- Travis Porco,
- Stephen McLeod,
- Kuniyoshi Kanai,
- Meredith Whiteside,
- Steven Yeh,
- Tolulope Fashina,
- James Chodosh,
- Bridgit Tarkap,
- Jambi N. Garap,
- Magdalene Mangot,
- Edwin Amel,
- Fasihah Taleo,
- Johnson Kasso,
- Kalbule Willie,
- Madopule Nanu,
- Prudence Rymill,
- Anthony W. Solomon
Affiliations
- Huy Tran
- Hai Yen Vision Institute, Ho Chi Minh City, Vietnam
- Thao Ha
- Hai Yen Vision Institute, Ho Chi Minh City, Vietnam
- Linh Hoang
- Hai Yen Vision Institute, Ho Chi Minh City, Vietnam
- Yen Tran
- Hai Yen Vision Institute, Ho Chi Minh City, Vietnam
- Kevin Ruder
- Francis I. Proctor Foundation, University of California, San Francisco, USA
- Lina Zhong
- Francis I. Proctor Foundation, University of California, San Francisco, USA
- Cindi Chen
- Francis I. Proctor Foundation, University of California, San Francisco, USA
- YuHeng Liu
- Francis I. Proctor Foundation, University of California, San Francisco, USA
- Danny Yu
- Francis I. Proctor Foundation, University of California, San Francisco, USA
- Thomas Abraham
- Francis I. Proctor Foundation, University of California, San Francisco, USA
- Armin Hinterwirth
- Francis I. Proctor Foundation, University of California, San Francisco, USA
- Michael Deiner
- Department of Ophthalmology, University of California, San Francisco, USA
- Travis C. Porco
- Department of Ophthalmology, University of California, San Francisco, USA
- Thomas M. Lietman
- Francis I. Proctor Foundation, University of California, San Francisco, USA; Department of Ophthalmology, University of California, San Francisco, USA
- Thuy Doan
- Francis I. Proctor Foundation, University of California, San Francisco, USA; Department of Ophthalmology, University of California, San Francisco, USA; Corresponding author.
- Gerami D. Seitzman
- Francis I. Proctor Foundation, University of California, San Francisco, USA; Department of Ophthalmology, University of California, San Francisco, USA
- Lalitha Prajna
- Aravind Eye Hospital, Madurai, India
- N. Venkatesh Prajna
- Aravind Eye Hospital, Madurai, India
- Ramesh Gunasekaran
- Aravind Eye Hospital, Madurai, India
- Sankalp Singh Sharma
- Aravind Eye Hospital, Madurai, India
- Vishnu Teja
- Aravind Eye Hospital, Madurai, India
- Meenu Chaudhary
- B.P Koirala Lions Center for Ophthalmic Studies, Kathmandu, Nepal
- Sanjeeta Sitaula
- B.P Koirala Lions Center for Ophthalmic Studies, Kathmandu, Nepal
- Ali Sié
- Centre de Recherche en Sante de Nouna, Nouna, Burkina Faso
- Boubacar Coulibaly
- Centre de Recherche en Sante de Nouna, Nouna, Burkina Faso
- Mamadou Bountogo
- Centre de Recherche en Sante de Nouna, Nouna, Burkina Faso
- Thanapong Somkijrungroj
- Chulalongkorn University, Bangkok, Thailand
- Vannarut Satitpitakul
- Chulalongkorn University, Bangkok, Thailand
- Huy Tran
- Hai Yen Vision Institute, Ho Chi Minh City, Vietnam
- Linh Hoàng Mai
- Hai Yen Vision Institute, Ho Chi Minh City, Vietnam
- Thảo Hạ Xuân
- Hai Yen Vision Institute, Ho Chi Minh City, Vietnam
- Yen Tran
- Hai Yen Vision Institute, Ho Chi Minh City, Vietnam
- Cristhian A. Urzua
- Hospital Clinico Universidad de Chile, Santiago, Chile
- Fabian Vega
- Hospital Clinico Universidad de Chile, Santiago, Chile
- Felipe Salgado
- Hospital Clinico Universidad de Chile, Santiago, Chile
- Loreto Cuitino
- Hospital Clinico Universidad de Chile, Santiago, Chile
- Fernando Pérez Pérez
- Instituto Mexicano de Oftalmología, Santiago de Querétaro, Mexico
- Jaime Macías Martínez
- Instituto Mexicano de Oftalmología, Santiago de Querétaro, Mexico
- Van Charles Lansingh
- Instituto Mexicano de Oftalmología, Santiago de Querétaro, Mexico
- Sukhumal Thanapaisal
- Khon Kaen University, Khon Kaen, Thailand
- Wipada Laovirojjanakul
- Khon Kaen University, Khon Kaen, Thailand
- George McKie, Program Officer
- National Eye Institute
- Kenia Chavez
- Oregon Health and Science University, Portland, Oregon, USA
- Travis Redd
- Oregon Health and Science University, Portland, Oregon, USA
- Winston Chamberlain
- Oregon Health and Science University, Portland, Oregon, USA
- Angel Cheng
- Pacific Vision Institute of Hawaii, Honolulu, Hawaii, USA
- Vivien Tham
- Pacific Vision Institute of Hawaii, Honolulu, Hawaii, USA
- Wiwan Sansanayudh
- Phramongkutklao Hospital, Bangkok, Thailand
- Abba Kaka Hajia Yakoura
- Programme National de Santé Oculaire, Niamey, Niger
- Abdou Amza
- Programme National de Santé Oculaire, Niamey, Niger
- Abdoul Salam Youssoufou Souley
- Programme National de Santé Oculaire, Niamey, Niger
- Adam Nouhou Diori
- Programme National de Santé Oculaire, Niamey, Niger
- Beido Nassirou
- Programme National de Santé Oculaire, Niamey, Niger
- Boubacar Kadri
- Programme National de Santé Oculaire, Niamey, Niger
- Boubacar Mariama
- Programme National de Santé Oculaire, Niamey, Niger
- Cissé Mamadou Ibrahim
- Programme National de Santé Oculaire, Niamey, Niger
- Lamyne Aboubacar Roufaye
- Programme National de Santé Oculaire, Niamey, Niger
- Ramatou Boulhassane
- Programme National de Santé Oculaire, Niamey, Niger
- Saley Ali
- Programme National de Santé Oculaire, Niamey, Niger
- Zakou Abdou
- Programme National de Santé Oculaire, Niamey, Niger
- Lee Goren
- Rabin Medical Center, Petah Tikva, Israel
- Irit Bahar
- Rabin Medical Center, Petah Tikva, Israel
- Ruti Sella
- Rabin Medical Center, Petah Tikva, Israel
- Clare Kelliher
- Sinai Hospital, Baltimore, Maryland, USA
- Laura Green
- Sinai Hospital, Baltimore, Maryland, USA
- Hon Shing Ong
- Singapore Eye Research Institute, Singapore
- Jod Mehta
- Singapore Eye Research Institute, Singapore
- Yu-Chi Liu
- Singapore Eye Research Institute, Singapore
- Benjamin A. Pinsky
- Stanford University School of Medicine
- De-Kuang Hwang
- Taipei Veterans General Hospital, Taipei, Taiwan
- Nai-Wen Fan
- Taipei Veterans General Hospital, Taipei, Taiwan
- Hong Sheng Chiong
- The University of Sydney, Save Sight Institute, Sydney, Australia
- Javier Lacorzana
- The University of Sydney, Save Sight Institute, Sydney, Australia
- Maria Cabrera-Aguas
- The University of Sydney, Save Sight Institute, Sydney, Australia
- Stephanie Watson
- The University of Sydney, Save Sight Institute, Sydney, Australia
- Edmund Tsui
- University of California Los Angeles Stein Eye Institute, Los Angeles, California, USA
- Nina M. Cherian
- University of California Los Angeles Stein Eye Institute, Los Angeles, California, USA
- Rachel Feit-Leichman
- University of California Los Angeles Stein Eye Institute, Los Angeles, California, USA
- Reginald E. Hughes, Jr
- University of California Los Angeles Stein Eye Institute, Los Angeles, California, USA
- Tania Onclinx
- University of California Los Angeles Stein Eye Institute, Los Angeles, California, USA
- Joseph K Privratsky
- University of California Los Angeles Stein Eye Institute, Los Angeles, California, USA
- Carol Yu
- University of California San Diego Shiley Eye Institute, La Jolla, California, USA
- Esmeralda McClean
- University of California San Diego Shiley Eye Institute, La Jolla, California, USA
- Iliana Molina
- University of California San Diego Shiley Eye Institute, La Jolla, California, USA
- Armin Hinterwirth
- University of California San Francisco Francis I. Proctor Foundation, San Francisco, California, USA
- Cindi Chen
- University of California San Francisco Francis I. Proctor Foundation, San Francisco, California, USA
- Danny Yu
- University of California San Francisco Francis I. Proctor Foundation, San Francisco, California, USA
- David Liu
- University of California San Francisco Francis I. Proctor Foundation, San Francisco, California, USA
- Elodie Lebas
- University of California San Francisco Francis I. Proctor Foundation, San Francisco, California, USA
- Emily Colby
- University of California San Francisco Francis I. Proctor Foundation, San Francisco, California, USA
- Gerami Seitzman
- University of California San Francisco Francis I. Proctor Foundation, San Francisco, California, USA
- Kevin Ruder
- University of California San Francisco Francis I. Proctor Foundation, San Francisco, California, USA
- Lina Zhong
- University of California San Francisco Francis I. Proctor Foundation, San Francisco, California, USA
- Michael Deiner
- University of California San Francisco Francis I. Proctor Foundation, San Francisco, California, USA
- Thomas Abraham
- University of California San Francisco Francis I. Proctor Foundation, San Francisco, California, USA
- Thomas Lietman
- University of California San Francisco Francis I. Proctor Foundation, San Francisco, California, USA
- Thuy Doan, Principal Investigator
- University of California San Francisco Francis I. Proctor Foundation, San Francisco, California, USA
- Travis Porco
- University of California San Francisco Francis I. Proctor Foundation, San Francisco, California, USA
- Stephen McLeod
- University of California San Francisco Francis I. Proctor Foundation, San Francisco, California, USA
- Kuniyoshi Kanai
- University of California Berkeley School of Optometry, Berkeley, California, USA
- Meredith Whiteside
- University of California Berkeley School of Optometry, Berkeley, California, USA
- Steven Yeh
- University of Nebraska Medical Center Truhlsen Eye Institute, Omaha, Nebraska, USA
- Tolulope Fashina
- University of Nebraska Medical Center Truhlsen Eye Institute, Omaha, Nebraska, USA
- James Chodosh
- University of New Mexico, Albuquerque, New Mexico
- Bridgit Tarkap
- University of Papua New Guinea School of Medicine and Health Sciences, Port Moresby, Papua New Guinea
- Jambi N. Garap
- University of Papua New Guinea School of Medicine and Health Sciences, Port Moresby, Papua New Guinea
- Magdalene Mangot
- University of Papua New Guinea School of Medicine and Health Sciences, Port Moresby, Papua New Guinea
- Edwin Amel
- Vanuatu Eye Program, Ministry of Health, Vanuatu
- Fasihah Taleo
- Vanuatu Eye Program, Ministry of Health, Vanuatu
- Johnson Kasso
- Vanuatu Eye Program, Ministry of Health, Vanuatu
- Kalbule Willie
- Vanuatu Eye Program, Ministry of Health, Vanuatu
- Madopule Nanu
- Vanuatu Eye Program, Ministry of Health, Vanuatu
- Prudence Rymill
- Vanuatu Eye Program, Ministry of Health, Vanuatu
- Anthony W. Solomon
- World Health Organization
- Journal volume & issue
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Vol. 146
p. 107133
Abstract
Objectives: To determine the associated pathogen during the 2023 conjunctivitis outbreak in Vietnam Methods: RNA-sequencing was used to identify pathogens before and during the outbreak. Results: 24 patients with infectious conjunctivitis between March and October 2023 from Hai Yen Vision Institute in Vietnam were swabbed. Coxsackievirus A24v was the most common pathogen identified. Phylogenetic analysis of these strains demonstrates similarities to the Coxsackievirus identified in the 2022 India outbreak. Human adenovirus D was also circulating. Ocular findings of tearing, purulence, and itching were common in this outbreak. Conclusions: Multiple viruses can co-circulate during conjunctivitis outbreaks. Hemorrhagic conjunctivitis, commonly associated with coxsackievirus conjunctivitis, was not a common clinical sign in this outbreak. Repeat genetic surveillance, with the notable inclusion of RNA virus detection strategies, is important for outbreak detection.
