Granulocytic sarcoma: A case series and review

Abstract

Granulocytic sarcomas (GSs) are rare, solid, extramedullary tumors composed of immature myeloid cells. They can be seen before, concomitantly with or after a diagnosis of acute myeloid leukemia, chronic myeloid leukemia, or myelodysplastic syndromes. We report four unusual presentations of granulocytic sarcoma treated at our center. Due to the rarity of the disease, it is difficult to conduct randomized controlled trials, and hence, there are no consensus for the treatment of GS. Most of the isolated GS frequently progress to acute myeloid leukemia, and all GSs tend to have a poor prognosis.

Keywords

• acute myeloid leukemia
• chemotherapy
• chronic myeloid leukemia
• granulocytic sarcoma
• imatinib