Nature Communications (Jan 2019)

Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis

  • Kamil Sołtysik,
  • Yuki Ohsaki,
  • Tsuyako Tatematsu,
  • Jinglei Cheng,
  • Toyoshi Fujimoto

DOI
https://doi.org/10.1038/s41467-019-08411-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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The origin and physiological significance of lipid droplets (LDs) in the nucleus is not clear. Here authors show that nucleoplasmic LDs in hepatocytes are derived from apolipoprotein B (ApoB)-free lumenal LDs and constitute a feedback mechanism to regulate PC synthesis in accordance with ER stress.