Frontiers in Oncology (Sep 2023)
Regulation of iron metabolism and ferroptosis in cancer stem cells
- Hailiang Wang,
- Hailiang Wang,
- Hailiang Wang,
- Zhongyan Zhang,
- Zhongyan Zhang,
- Zhongyan Zhang,
- Shiye Ruan,
- Shiye Ruan,
- Shiye Ruan,
- Qian Yan,
- Qian Yan,
- Yubin Chen,
- Yubin Chen,
- Jinwei Cui,
- Jinwei Cui,
- Xinjian Wang,
- Shanzhou Huang,
- Shanzhou Huang,
- Shanzhou Huang,
- Shanzhou Huang,
- Baohua Hou,
- Baohua Hou,
- Baohua Hou,
- Baohua Hou
Affiliations
- Hailiang Wang
- Department of Hepatobiliary Surgery, Weihai Central Hospital Affiliated to Qingdao University, Weihai, China
- Hailiang Wang
- Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
- Hailiang Wang
- The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China
- Zhongyan Zhang
- Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
- Zhongyan Zhang
- The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China
- Zhongyan Zhang
- Department of General Surgery, Heyuan People’s Hospital, Heyuan, China
- Shiye Ruan
- Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
- Shiye Ruan
- The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China
- Shiye Ruan
- Department of General Surgery, Heyuan People’s Hospital, Heyuan, China
- Qian Yan
- Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
- Qian Yan
- Department of General Surgery, Heyuan People’s Hospital, Heyuan, China
- Yubin Chen
- Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
- Yubin Chen
- Department of General Surgery, Heyuan People’s Hospital, Heyuan, China
- Jinwei Cui
- Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
- Jinwei Cui
- Department of General Surgery, Heyuan People’s Hospital, Heyuan, China
- Xinjian Wang
- Department of Hepatobiliary Surgery, Weihai Central Hospital Affiliated to Qingdao University, Weihai, China
- Shanzhou Huang
- Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
- Shanzhou Huang
- The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China
- Shanzhou Huang
- Department of General Surgery, Heyuan People’s Hospital, Heyuan, China
- Shanzhou Huang
- Department of General Surgery, South China University of Technology School of Medicine, Guangzhou, China
- Baohua Hou
- Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
- Baohua Hou
- The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China
- Baohua Hou
- Department of General Surgery, Heyuan People’s Hospital, Heyuan, China
- Baohua Hou
- Department of General Surgery, South China University of Technology School of Medicine, Guangzhou, China
- DOI
- https://doi.org/10.3389/fonc.2023.1251561
- Journal volume & issue
-
Vol. 13
Abstract
The ability of cancer stem cells (CSCs) to self-renew, differentiate, and generate new tumors is a significant contributor to drug resistance, relapse, and metastasis. Therefore, the targeting of CSCs for treatment is particularly important. Recent studies have demonstrated that CSCs are more susceptible to ferroptosis than non-CSCs, indicating that this could be an effective strategy for treating tumors. Ferroptosis is a type of programmed cell death that results from the accumulation of lipid peroxides caused by intracellular iron-mediated processes. CSCs exhibit different molecular characteristics related to iron and lipid metabolism. This study reviews the alterations in iron metabolism, lipid peroxidation, and lipid peroxide scavenging in CSCs, their impact on ferroptosis, and the regulatory mechanisms underlying iron metabolism and ferroptosis. Potential treatment strategies and novel compounds targeting CSC by inducing ferroptosis are also discussed.
Keywords
