World Journal of Surgical Oncology (Dec 2012)

Different distribution of breast ductal carcinoma <it>in situ</it>, ductal carcinoma <it>in situ</it> with microinvasion, and invasion breast cancer

  • Wei Zhang,
  • Er-li Gao,
  • Yi-li Zhou,
  • Qi Zhai,
  • Zhang-yong Zou,
  • Gui-long Guo,
  • Guo-rong Chen,
  • Hua-min Zheng,
  • Guan-li Huang,
  • Xiao-hua Zhang

DOI
https://doi.org/10.1186/1477-7819-10-262
Journal volume & issue
Vol. 10, no. 1
p. 262

Abstract

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Abstract Background Breast ductal cancer in situ (DCIS) can recur or progress to invasive ductal cancer (IDC), and the interim stage include DCIS with microinvasion (DCIS-Mi). In this article, we attempt to study the study the differences of clinicopathological features, imaging data, and immunohistochemical-based subtypes among DCIS, DCIS-Mi, and IDC. Methods In this retrospective study, we attempt to compare the clinicopathological features, immunohistochemical results and imaging data of 866 patients (included 73 DCIS, 72 DCIS-Mi, and 721 IDC). Results Patients with DCIS and DCIS-Mi were younger than those with IDC (P = 0.007). DCIS and DCIS-Mi often happened in premenopausal women while IDC was opposite (P P P P P Conclusions Different clinicopathological, immunohistochemical, and imaging features among DCIS, DCIS-Mi, and IDC indicate that they are distinct entities. A larger sample size is needed for further study.

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