Brazilian Journal of Infectious Diseases (Jan 2002)

Human Papillomavirus prevalence, viral load and cervical intraepithelial neoplasia in HIV-infected women

  • Levi José E.,
  • Fink Maria C.S.,
  • Canto Cynthia L.M.,
  • Carretiero Nadily,
  • Matsubara Regina,
  • Linhares Iara,
  • Dores Gérson B. das,
  • Castelo Adauto,
  • Segurado Aluísio,
  • Uip David E.,
  • Eluf Neto José

Journal volume & issue
Vol. 6, no. 3
pp. 129 – 134

Abstract

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HIV-infected women from São Paulo city were enrolled in a cross-sectional study on Human Papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN) prevalence and their association with laboratory markers of AIDS, namely HIV viral load and CD4+ cell counts. A cervical specimen was collected and submitted to Hybrid Capture, a test for HPV viral load determination. HPV-DNA was detected in 173 of 265 women (64.5%). Twenty (7.5%) women were infected by one or more low-risk viruses, 89 (33%) by one or more high-risk viruses, and 64 (24%) harbored at least one HPV type from each risk group. Abnormal smears were observed in 19% of the patients, though there were no invasive carcinomas. Severely immunosuppressed patients (CD4/µL <100) were at the greatest risk of having a cytological abnormality and a high high-risk HPV viral load.

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