Zhongguo cuzhong zazhi (Oct 2023)
金纳多治疗血管性认知障碍的回顾性研究 Retrospective Study of Ginaton in the Treatment of Vascular Cognitive Impairment
Abstract
目的 评价金纳多改善血管性认知障碍的疗效。 方法 回顾性分析黑龙江中医药大学附属第一医院2018年1月—2020年5月因血管性认知障碍住院患者的临床及随访资料。按随访期间是否连续服用金纳多进行分组，使用倾向性评分法进行匹配，观察随访2年后MoCA和功能活动问卷（functional activites questionnaire，FAQ）评分，评估金纳多的疗效。 结果 共纳入233例患者，金纳多组59例，对照组174例。无放回倾向性评分匹配后，金纳多组和对照组各匹配56例，两组基线差异无统计学意义。2年随访结束时，两组MoCA评分均较治疗前降低 （P＜0.001），金纳多组MoCA评分优于对照组，差异有统计学意义（P=0.029）；金纳多组FAQ评分较治疗前无明显改变（P=0.059），对照组FAQ评分明显增高，差异有统计学意义（P＜0.001），两组2年随访FAQ评分差异无统计学意义（P=0.136）。 结论 金纳多有助于缓解血管性认知障碍患者认知功能下降，维持患者日常生活能力。 Abstract: Objective To evaluate the effect of Ginaton on vascular cognitive impairment. Methods A retrospective analysis was conducted on clinical and follow-up data of patients with vascular cognitive impairment from the First Affiliated Hospital, Heilongjiang University of Chinese Medicine from January 2018 to May 2020. Patients were grouped according to whether or not they received continuous Ginaton during the follow-up period, and then matched using a propensity score. After 2 years of follow-up, the MoCA and functional activities questionnaire (FAQ) scores were observed to evaluate the efficacy of Ginaton. Results A total of 233 patients were included, 59 in the Ginaton group and 174 in the control group. Noreplacement propensity score matching was performed, 56 cases were matched in the Ginaton group and control group respectively, and there was no significant difference between the two groups at baseline. At the end of follow-up, the MoCA scores of both groups decreased (P<0.001), and the MoCA score of the Ginaton group was better than control group, with statistical difference (P=0.029) . At the same time, the FAQ score of the Ginaton group had no significant change (P=0.059), while the FAQ score of the control group had a significant increase (P<0.001) . There was no significant difference in FAQ scores between the two groups during 2-year follow-up (P=0.136) . Conclusions Ginaton can alleviate the cognitive decline of patients with vascular cognitive impairment and maintain the ability of daily living.
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