Communications Biology (Nov 2022)

Poly ADP-ribosylation of SET8 leads to aberrant H4K20 methylation in mammalian nuclear genome

  • Pierre-Olivier Estève,
  • Sagnik Sen,
  • Udayakumar S. Vishnu,
  • Cristian Ruse,
  • Hang Gyeong Chin,
  • Sriharsa Pradhan

DOI
https://doi.org/10.1038/s42003-022-04241-8
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 18

Abstract

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SET8 is post-translationally poly ADPribosylated by PARP1 on several lysine residues, leading to SET8 degradation via ubiquitylation and genome-wide aberrant H4K20 methylation.