Journal of Microbiology, Immunology and Infection (Feb 2018)

Impact of reduced tigecycline susceptibility on clinical outcomes of Acinetobacter bacteremia

  • Yea-Yuan Chang,
  • Yuag-Meng Liu,
  • Chang-Pan Liu,
  • Shu-Chen Kuo,
  • Te-Li Chen,
  • Yea-Yuan Chang,
  • Yuag-Meng Liu,
  • Shu-Chen Kuo,
  • Chang-Pan Liu,
  • Te-Li Chen,
  • Yi-Tzu Lee,
  • Ya-Sung Yang

DOI
https://doi.org/10.1016/j.jmii.2017.08.024
Journal volume & issue
Vol. 51, no. 1
pp. 148 – 152

Abstract

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The higher 14-day mortality rate for patients with Acinetobacter bacteremia receiving tigecycline appropriately compared to other appropriate antibiotics (36.4% versus 14.2%, P = 0.028) was due to the poor effect of tigecycline for isolates with a minimum inhibitory concentration of 2 μg/mL (63.6% of 11 versus 14.2% of 127, P = 0.001).

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