Nature Communications (Apr 2022)
Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model
- Qizhou Lian,
- Kui Zhang,
- Zhao Zhang,
- Fuyu Duan,
- Liyan Guo,
- Weiren Luo,
- Bobo Wing-Yee Mok,
- Abhimanyu Thakur,
- Xiaoshan Ke,
- Pedram Motallebnejad,
- Vlad Nicolaescu,
- Jonathan Chen,
- Chui Yan Ma,
- Xiaoya Zhou,
- Shuo Han,
- Teng Han,
- Wei Zhang,
- Adrian Y. Tan,
- Tuo Zhang,
- Xing Wang,
- Dong Xu,
- Jenny Xiang,
- Aimin Xu,
- Can Liao,
- Fang-Ping Huang,
- Ya-Wen Chen,
- Jie Na,
- Glenn Randall,
- Hung-fat Tse,
- Zhiwei Chen,
- Yin Chen,
- Huanhuan Joyce Chen
Affiliations
- Qizhou Lian
- Cord Blood Bank Center, Cord Blood Bank, Guangzhou Institute of Eugenics and Perinatology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University
- Kui Zhang
- The Pritzker School of Molecular Engineering, the University of Chicago
- Zhao Zhang
- HKUMed Laboratory of Cellular Therapeutics, and Department of Medicine, the University of Hong Kong
- Fuyu Duan
- Cord Blood Bank Center, Cord Blood Bank, Guangzhou Institute of Eugenics and Perinatology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University
- Liyan Guo
- Cord Blood Bank Center, Cord Blood Bank, Guangzhou Institute of Eugenics and Perinatology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University
- Weiren Luo
- Department of Pathology, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen Third People’s Hospital, National Clinical Research Centre for Infectious Diseases
- Bobo Wing-Yee Mok
- Department of Microbiology and State Key Laboratory for Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Abhimanyu Thakur
- The Pritzker School of Molecular Engineering, the University of Chicago
- Xiaoshan Ke
- The Pritzker School of Molecular Engineering, the University of Chicago
- Pedram Motallebnejad
- The Pritzker School of Molecular Engineering, the University of Chicago
- Vlad Nicolaescu
- Microbiology, Biosciences Division, the University of Chicago
- Jonathan Chen
- McCormick School of Engineering, Northwestern University
- Chui Yan Ma
- Cord Blood Bank Center, Cord Blood Bank, Guangzhou Institute of Eugenics and Perinatology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University
- Xiaoya Zhou
- HKUMed Laboratory of Cellular Therapeutics, and Department of Medicine, the University of Hong Kong
- Shuo Han
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Teng Han
- Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine
- Wei Zhang
- Genomic Resource Core Facility, Weill Cornell Medicine
- Adrian Y. Tan
- Genomic Resource Core Facility, Weill Cornell Medicine
- Tuo Zhang
- Genomic Resource Core Facility, Weill Cornell Medicine
- Xing Wang
- Genomic Resource Core Facility, Weill Cornell Medicine
- Dong Xu
- Genomic Resource Core Facility, Weill Cornell Medicine
- Jenny Xiang
- Genomic Resource Core Facility, Weill Cornell Medicine
- Aimin Xu
- State Key Laboratory of Pharmaceutical Biotechnology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Can Liao
- Cord Blood Bank Center, Cord Blood Bank, Guangzhou Institute of Eugenics and Perinatology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University
- Fang-Ping Huang
- Institute for Advanced Study (IAS), Shenzhen University
- Ya-Wen Chen
- Department of Otolaryngology, Icahn School of Medicine at Mount Sinai
- Jie Na
- School of Medicine, Tsinghua University
- Glenn Randall
- Microbiology, Biosciences Division, the University of Chicago
- Hung-fat Tse
- HKUMed Laboratory of Cellular Therapeutics, and Department of Medicine, the University of Hong Kong
- Zhiwei Chen
- AIDS Institute and Department of Microbiology, State Key Laboratory of Emergent Infectious Disease, The University of Hong Kong
- Yin Chen
- Department of Pharmacology and Toxicology, School of Pharmacy, University of Arizona
- Huanhuan Joyce Chen
- The Pritzker School of Molecular Engineering, the University of Chicago
- DOI
- https://doi.org/10.1038/s41467-022-29731-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Model systems to study SARS-CoV-2 infection are required to better understand the immune response. Here the authors use a lung and macrophage co-culture system by differentiation of human pluripotent stem cells to better understand the phenotype and gene expression changes in host lung cells and macrophages after SARS-CoV-2 infection in vitro.
