Nature Communications (Mar 2023)
The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma
- Lucia Morgado-Palacin,
- Jessie A. Brown,
- Thomas F. Martinez,
- Juana M. Garcia-Pedrero,
- Farhad Forouhar,
- S. Aidan Quinn,
- Clara Reglero,
- Joan Vaughan,
- Yasamin Hajy Heydary,
- Cynthia Donaldson,
- Sandra Rodriguez-Perales,
- Eva Allonca,
- Rocio Granda-Diaz,
- Agustin F. Fernandez,
- Mario F. Fraga,
- Arianna L. Kim,
- Jorge Santos-Juanes,
- David M. Owens,
- Juan P. Rodrigo,
- Alan Saghatelian,
- Adolfo A. Ferrando
Affiliations
- Lucia Morgado-Palacin
- Institute for Cancer Genetics, Columbia University
- Jessie A. Brown
- Institute for Cancer Genetics, Columbia University
- Thomas F. Martinez
- Department of Pharmaceutical Sciences, University of California
- Juana M. Garcia-Pedrero
- Department of Otolaryngology, Hospital Universitario Central de Asturias (HUCA)
- Farhad Forouhar
- Proteomics and Macromolecular Crystallography Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University
- S. Aidan Quinn
- Institute for Cancer Genetics, Columbia University
- Clara Reglero
- Institute for Cancer Genetics, Columbia University
- Joan Vaughan
- Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies
- Yasamin Hajy Heydary
- Department of Pharmaceutical Sciences, University of California
- Cynthia Donaldson
- Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies
- Sandra Rodriguez-Perales
- Molecular Cytogenetics Group, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncológicas (CNIO)
- Eva Allonca
- Department of Otolaryngology, Hospital Universitario Central de Asturias (HUCA)
- Rocio Granda-Diaz
- Department of Otolaryngology, Hospital Universitario Central de Asturias (HUCA)
- Agustin F. Fernandez
- Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)
- Mario F. Fraga
- Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)
- Arianna L. Kim
- Department of Dermatology, Columbia University Irving Medical Center
- Jorge Santos-Juanes
- Department of Dermatology, Hospital Universitario Central de Asturias (HUCA)
- David M. Owens
- Department of Dermatology, Columbia University Irving Medical Center
- Juan P. Rodrigo
- Department of Otolaryngology, Hospital Universitario Central de Asturias (HUCA)
- Alan Saghatelian
- Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies
- Adolfo A. Ferrando
- Institute for Cancer Genetics, Columbia University
- DOI
- https://doi.org/10.1038/s41467-023-36713-8
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 14
Abstract
TINCR encodes a p53-regulated ubiquitin-like microprotein expressed in stratified epithelia. Tincr loss promotes UVB-induced skin carcinogenesis in mice and deletions and mutations in human squamous cell carcinoma support a tumor suppressor role.
