The Evolution of Antisense Oligonucleotide Chemistry—A Personal Journey

Abstract

Over the last four decades, tremendous progress has been made in use of synthetic oligonucleotides as therapeutics. This has been possible largely by introducing chemical modifications to provide drug like properties to oligonucleotides. In this article I have summarized twists and turns on use of chemical modifications and their road to success and highlight areas of future directions.

Keywords

• oligonucleotide
• therapeutic
• antisense
• medicinal chemistry
• structure activity relationship