Research progress of drugs targeting ferroptosis for the treatment of non-alcoholic fatty liver disease

Abstract

Emerging evidence indicates that ferroptosis, an iron-dependent form of regulated cell death, plays a critical role in the pathological progression of non-alcoholic fatty liver disease (NAFLD). Ferroptosis involves in the pathogenesis of NAFLD and drugs targeting at ferroptosis by its inhibitors can alleviate the progression of NAFLD both in vitro and in vivo. Pharmacological inhibition of ferroptosis might be a potential strategy of NAFLD treatment.

Keywords

• non-alcoholic fatty liver disease(nafld)|non-alcoholic steatohepatitis(nash)|ferroptosis|ferroptosis inhibitor