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Risk factors for recurrent wheezing in infants: a case-control study

Revista de Saúde Pública. 2016;50(0) DOI 10.1590/S1518-8787.2016050005100


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Journal Title: Revista de Saúde Pública

ISSN: 0034-8910 (Print); 1518-8787 (Online)

Publisher: Universidade de São Paulo

LCC Subject Category: Medicine: Public aspects of medicine

Country of publisher: Brazil

Language of fulltext: English, Spanish, Portuguese

Full-text formats available: PDF, HTML, XML



Roberta Barros de Sousa

Décio Medeiros

Emanuel Sarinho

José Ângelo Rizzo

Almerinda Rêgo Silva

Ana Carolina Dela Bianca


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Editorial Board

Instructions for authors

Time From Submission to Publication: 13 weeks


Abstract | Full Text

ABSTRACT OBJECTIVE To evaluate the association between recurrent wheezing and atopy, the Asthma Predictive Index, exposure to risk factors, and total serum IgE levels as potential factors to predict recurrent wheezing. METHODS A case-control study with infants aged 6-24 months treated at a specialized outpatient clinic from November 2011 to March 2013. Evaluations included sensitivity to inhalant and food antigens, positive Asthma Predictive Index, and other risk factors for recurrent wheezing (smoking during pregnancy, presence of indoor smoke, viral infections, and total serum IgE levels). RESULTS We evaluated 113 children: 65 infants with recurrent wheezing (63.0% male) with a mean age of 14.8 (SD = 5.2) months and 48 healthy infants (44.0% male) with a mean age of 15.2 (SD = 5.1) months. In the multiple analysis model, antigen sensitivity (OR = 12.45; 95%CI 1.28–19.11), positive Asthma Predictive Index (OR = 5.57; 95%CI 2.23–7.96), and exposure to environmental smoke (OR = 2.63; 95%CI 1.09–6.30) remained as risk factors for wheezing. Eosinophilia ≥ 4.0% e total IgE ≥ 100 UI/mL were more prevalent in the wheezing group, but failed to remain in the model. Smoking during pregnancy was identified in a small number of mothers, and secondhand smoke at home was higher in the control group. CONCLUSIONS Presence of atopy, positive Asthma Predictive Index and exposure to environmental smoke are associated to recurrent wheezing. Identifying these factors enables the adoption of preventive measures, especially for children susceptible to persistent wheezing and future asthma onset.