Nature Communications (Jul 2022)

Cigarette smoke aggravates asthma by inducing memory-like type 3 innate lymphoid cells

  • Jongho Ham,
  • Jihyun Kim,
  • Kyoung-Hee Sohn,
  • In-Won Park,
  • Byoung-Whui Choi,
  • Doo Hyun Chung,
  • Sang-Heon Cho,
  • Hye Ryun Kang,
  • Jae-Woo Jung,
  • Hye Young Kim

DOI
https://doi.org/10.1038/s41467-022-31491-1
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

Read online

Cigarette smoking may exacerbate asthma, but the underlying mechanisms have not been studied extensively in human patients. Here authors show that type 3 innate lymphoid cells with activated phenotypes are found in the sputum and blood of smokers in higher frequencies, which might result in the aggravation of asthma.