An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes

Steven Batinovic; Emma McHugh; Scott A. Chisholm; Kathryn Matthews; Boiyin Liu; Laure Dumont; Sarah C. Charnaud; Molly Parkyn Schneider; Paul R. Gilson; Tania F. de Koning-Ward; Matthew W. A. Dixon; Leann Tilley

doi:10.1038/ncomms16044

Nature Communications (Jul 2017)

An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes

Steven Batinovic,
Emma McHugh,
Scott A. Chisholm,
Kathryn Matthews,
Boiyin Liu,
Laure Dumont,
Sarah C. Charnaud,
Molly Parkyn Schneider,
Paul R. Gilson,
Tania F. de Koning-Ward,
Matthew W. A. Dixon,
Leann Tilley

Affiliations

Steven Batinovic: Department of Biochemistry and Molecular Biology, Bio21 Institute, The University of Melbourne
Emma McHugh: Department of Biochemistry and Molecular Biology, Bio21 Institute, The University of Melbourne
Scott A. Chisholm: School of Medicine, Deakin University
Kathryn Matthews: School of Medicine, Deakin University
Boiyin Liu: Department of Biochemistry and Molecular Biology, Bio21 Institute, The University of Melbourne
Laure Dumont: Department of Biochemistry and Molecular Biology, Bio21 Institute, The University of Melbourne
Sarah C. Charnaud: Macfarlane Burnet Institute for Medical Research and Public Health
Molly Parkyn Schneider: Department of Biochemistry and Molecular Biology, Bio21 Institute, The University of Melbourne
Paul R. Gilson: Macfarlane Burnet Institute for Medical Research and Public Health
Tania F. de Koning-Ward: School of Medicine, Deakin University
Matthew W. A. Dixon: Department of Biochemistry and Molecular Biology, Bio21 Institute, The University of Melbourne
Leann Tilley: Department of Biochemistry and Molecular Biology, Bio21 Institute, The University of Melbourne

DOI: https://doi.org/10.1038/ncomms16044
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Plasmodium-infected red blood cells export virulence factors, such asPfEMP1, to the cell surface. Here, the authors identify a protein complex termed EPIC that interacts with PfEMP1 during export, and they show that knockdown of an EPIC component affects parasite virulence.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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