Insulin resistance and generation of advanced glycation end products

Abstract

Diabetes mellitus type 2 is one of the most frequently diagnosed diseases and in the long-term leads to a variety of complications. One of the mechanisms involved in these effects is insulin resistance which prevents glucose from being used by the different target organs and tissues, which in turn leads to structural and functional changes at the cellular level. In this context, the formation of advanced glycation end products has attained special importance as they have been implicated in several degenerative processes. It thus becomes necessary to look into potential therapeutic targets with the purpose of improving prognosis and quality of life of patients suffering from these diseases.

Keywords

• insulin resistance
• advanced glycation end products
• receptor for advanced glycation end products (RAGE)