Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer

Yuji Kubota; Yuko Fujioka; Ashwini Patil; Yusuke Takagi; Daisuke Matsubara; Masatomi Iijima; Isao Momose; Ryosuke Naka; Kenta Nakai; Nobuo N. Noda; Mutsuhiro Takekawa

doi:10.1038/s41467-022-31690-w

Nature Communications (Jul 2022)

Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer

Yuji Kubota,
Yuko Fujioka,
Ashwini Patil,
Yusuke Takagi,
Daisuke Matsubara,
Masatomi Iijima,
Isao Momose,
Ryosuke Naka,
Kenta Nakai,
Nobuo N. Noda,
Mutsuhiro Takekawa

Affiliations

Yuji Kubota: Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of Tokyo
Yuko Fujioka: Institute of Microbial Chemistry, Microbial Chemistry Research Foundation
Ashwini Patil: Laboratory of Functional Analysis In Silico, Human Genome Center, Institute of Medical Science, The University of Tokyo
Yusuke Takagi: Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of Tokyo
Daisuke Matsubara: Molecular Pathology Laboratory, Institute of Medical Science, The University of Tokyo
Masatomi Iijima: Institute of Microbial Chemistry, Microbial Chemistry Research Foundation
Isao Momose: Institute of Microbial Chemistry, Microbial Chemistry Research Foundation
Ryosuke Naka: Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of Tokyo
Kenta Nakai: Laboratory of Functional Analysis In Silico, Human Genome Center, Institute of Medical Science, The University of Tokyo
Nobuo N. Noda: Institute of Microbial Chemistry, Microbial Chemistry Research Foundation
Mutsuhiro Takekawa: Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-022-31690-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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MEK1 mutations are found in cancer and RASopathies, but their effects remain unclear. Here, the authors reveal a mutant MEK1 structure and qualitative differences in biological properties between the cancer- and RASopathy-associated mutants, providing insights into the pathophysiology, diagnosis, and treatment of these diseases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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